Abstract：
Three new Pt(II) complexes [(dpp-DAD)PtCl2] (I), [(Mes-DAD(Me)2)PtCl2] (II) and [(dpp-DAD(Me)2)PtCl2] (III) were synthesized by the direct reaction of [(CH3CN)2PtCl2] and corresponding redox-active 1,4-diaza-1,3-butadienes (DAD). The compounds were isolated in a single crystal form and their molecular structures were determined by X-ray diffraction. The purity of the complexes and their stability in solution was confirmed by NMR analysis. The Pt(II) ions in all compounds are in a square planar environment. The electrochemical reduction of complexes I-III proceeds in two successive cathodic stages. The first quasi-reversible reduction leads to the relatively stable monoanionic complexes; the second cathodic stage is irreversible. The coordination of 1,4-diaza-1,3-butadienes ligands with PtCl2 increases the reduction potential and the electron acceptor ability of the DAD ligands. The synthesized compounds were tested in relation to an adenocarcinoma of the ovary (SKOV3).
摘要：
三个新的Pt(II)配合物[(dpp-DAD)PtCl2](I),[(Mes-DAD(Me)2)PtCl2](II)和[(dpp-DAD(Me)2)PtCl2](III)通过[(CH3CN)2PtCl2]与相应的氧化还原活性1,4-二氮杂-1,3-丁二烯(DAD)的直接反应合成。以单晶形式分离化合物，并通过X射线衍射确定其分子结构。通过NMR分析证实络合物的纯度和它们在溶液中的稳定性。所有化合物中的Pt(II)离子均处于正方形平面环境中。络合物I-III的电化学还原在两个连续的阴极阶段中进行。第一次准可逆还原导致相对稳定的单阴离子络合物；第二个阴极阶段是不可逆的。1,4-二氮杂-1,3-丁二烯配体与PtCl2的配位增加了DAD配体的还原电势和电子受体能力。针对卵巢腺癌(SKOV3)测试合成的化合物。
