Abstract：
Cardiovascular disease caused by atherosclerosis (AS) seriously affects human health. Photothermal therapy (PTT) brings hope to the diagnosis and treatment of AS, with the development of nanotechnology. To improve treatment efficiency, self-assembled CuCo2S4 nanocrystals (NCs) were developed as a drug-delivery nanocarrier, triggered by near-infrared (NIR) light for efficient chemophotothermal therapy of arterial inflammation. The as-prepared self-assembled CuCo2S4 NCs exhibited excellent biocompatibility and a very high chloroquine (CL)-loading content. In addition, the self-assembled CuCo2S4 NCs/CL nanocomposites showed good photothermal performance, due to strong absorption in the NIR region, and the release of CL from the NCs/CL nanocomposites was driven by NIR light. When illuminated by NIR light, both PTT from the NCs and chemotherapy from the CL were simultaneously triggered, resulting in killing macrophages with a synergistic effect. Moreover, chemo-photothermal therapy with CuCo2S4 NCs/CL nanocomposites showed an effective therapeutic effect for arterial inflammation, in vivo. Our work demonstrated that chemo-photothermal therapy could be a promising strategy for the treatment of arterial inflammation against atherosclerosis.
摘要：
动脉粥样硬化(AS)引起的心血管疾病严重影响人类健康。光热疗法(PTT)给AS的诊断和治疗带来了希望,随着纳米技术的发展。为了提高治疗效率，自组装的CuCo2S4纳米晶体（NCs）被开发为药物递送纳米载体，由近红外（NIR）光触发，用于动脉炎症的有效化学光热治疗。制备的自组装CuCo2S4NC表现出优异的生物相容性和非常高的氯喹（CL）负载含量。此外,自组装CuCo2S4NCs/CL纳米复合材料表现出良好的光热性能,由于NIR区域的强吸收，NCs/CL纳米复合材料中CL的释放是由NIR光驱动的。当被NIR光照射时，来自NC的PTT和来自CL的化疗都同时被触发，导致杀死巨噬细胞具有协同作用。此外，化学光热疗法与CuCo2S4NCs/CL纳米复合材料显示了动脉炎症的有效治疗效果，在体内。我们的工作表明，化学光热疗法可能是治疗动脉粥样硬化炎症的有希望的策略。
