Abstract：
Blood-flow-restricted exercise (BFRE) has been gaining constantly increasing interest in rehabilitation, but its influence on endothelial functions has not been well studied yet. Our aim is to examine the influence of low-resistance BFRE on endothelial functions and angiogenesis. This prospective cross-over study involved 35 young healthy adults. They conducted a 21-min low-resistant exercise with blood flow restricted by pressure cuffs placed on arms and tights. They also did the same training but without blood flow restriction. Endothelial parameters and angiogenesis biomarkers were evaluated before and up to 20 min after exercise. Both types of exercise increased Flow-Mediated Dilatation (FMD) but elevation after BFRE was more significant compared to the controls. The stiffness index decreased only after BFRE, while the reflection index decreased significantly after both types of exercise but was higher after BFRE. Platelet endothelial cell adhesion molecule (PECAM-1) and vascular endothelial growth factor receptor 2 (VEGFR-2) concentrations were increased by both exercise types but elevations were higher after BFRE compared to the controls. Only BFRE elevated the mean serum CD34 protein concentration. Based on these results, we can assume that low-resistance BFR exercise stimulates angiogenesis and improves endothelial functions more significantly compared to the same training performed without blood flow restriction.
摘要：
血流受限运动（BFRE）对康复的兴趣不断增加，但其对内皮功能的影响尚未得到很好的研究。我们的目的是研究低抗性BFRE对内皮功能和血管生成的影响。这项前瞻性交叉研究涉及35名年轻健康成年人。他们进行了21分钟的低抵抗力运动，血液流动受到手臂和紧身衣上的压力袖带的限制。他们也做了同样的训练，但没有血流限制。在运动前和运动后20分钟内评估内皮参数和血管生成生物标志物。两种类型的运动都会增加流量介导的扩张（FMD），但与对照组相比，BFRE后的升高更为显着。刚度指数仅在BFRE后下降，而反射指数在两种类型的运动后均显着下降，但在BFRE后较高。两种运动类型都增加了血小板内皮细胞粘附分子（PECAM-1）和血管内皮生长因子受体2（VEGFR-2）的浓度，但与对照组相比，BFRE后的升高更高。只有BFRE升高了平均血清CD34蛋白浓度。基于这些结果,我们可以假设,与没有血流限制的相同训练相比,低阻力BFR运动更显著地刺激血管生成和改善内皮功能.
