Abstract：
After haematopoietic stem cell transplantation and a history of GVHD, the risk of developing secondary malignancies, including oral cancer, is higher. This risk increases with time post-transplantation; therefore, pediatric patients undergoing HSCT, who have long-term survival chances, are in a high-risk category. The aim of this review is to provide data on HSCT, GVHD, clinical manifestations, histological features and treatment of oral cancer, and outcomes in HSCT pediatric patients, affected by oral GVHD, who have been developed OSCC. Descriptive statistics were used to validate data. Fifteen studies on a total of 33 patients were selected. Data on oral cancer showed that the tongue was the most frequently involved site (13 pts; 39.39%), followed by the floor of the mouth (4 pts; 12.12%), and buccal mucosa (4 pts; 12.12%). Oral squamous cell carcinoma was the histological feature reported. There were 19 (57.58%) deaths occurring between 2 and 46.5 months after OC diagnosis. Eleven patients survived with a median follow-up of 34 months. Considering the high risk of developing oral cancer, a conventional oral examination every 6 months is recommended for HSCT pediatric patients who have developed GVHD.
摘要：
造血干细胞移植和GVHD病史后，发展为继发性恶性肿瘤的风险，包括口腔癌,更高。这种风险随着移植后的时间而增加；因此，接受HSCT的儿科患者，有长期生存机会的人，属于高风险类别。这项审查的目的是提供有关HSCT的数据，GVHD,临床表现，口腔癌的组织学特征和治疗，以及HSCT儿科患者的结果，受口腔GVHD影响，已经开发了OSCC。使用描述性统计来验证数据。共选择了33例患者的15项研究。有关口腔癌的数据显示，舌头是最常见的部位（13分；39.39％），其次是嘴底(4分；12.12%)，和颊粘膜（4分；12.12％）。据报道，口腔鳞状细胞癌是组织学特征。在OC诊断后2至46.5个月之间发生19例（57.58％）死亡。11例患者存活，中位随访时间为34个月。考虑到患口腔癌的风险很高，对于发生GVHD的HSCT儿科患者,建议每6个月进行一次常规口腔检查.
