Abstract：
Allergists addressing gastrointestinal (GI) symptoms during oral immunotherapy (OIT) may be biased toward diagnoses related to OIT; however, non-OIT causes may occur. Although there is currently a lack of robust data for evidence-based treatment recommendations, we provide 3 real-world illustrative cases along with a proposed management algorithm for GI symptoms encountered during OIT. This algorithm was developed because of a significant clinical need, given the number of new-to-OIT providers that include practicing allergists, trainees transitioning into practice, and allied health care providers who manage GI symptoms in OIT patients. We developed the algorithm based on the opinions of community and academic allergy clinics across Canada with significant clinical experience offering infant, preschool, and school-aged OIT patients, with gastroenterologist input. Further research is needed to fill the knowledge gaps in the management of GI symptoms during OIT before formal recommendations can be suggested.
摘要：
在口服免疫疗法（OIT）期间解决胃肠道（GI）症状的变态反应学家可能偏向于与OIT相关的诊断；然而，可能会出现非OIT原因。尽管目前缺乏基于证据的治疗建议的可靠数据，我们提供了3个真实世界的说明性案例，以及针对OIT期间遇到的GI症状的拟议管理算法。该算法是由于临床需要而开发的，考虑到包括执业过敏症患者在内的新OIT提供商的数量，学员过渡到实践，以及管理OIT患者胃肠道症状的专职医疗保健提供者。我们根据加拿大社区和学术过敏诊所的意见开发了该算法，这些诊所具有丰富的临床经验，提供婴儿，幼儿园，和学龄期OIT患者，胃肠病学家的意见。在提出正式建议之前，需要进一步的研究来填补OIT期间胃肠道症状管理的知识空白。
