Abstract：
Both clear cell odontogenic carcinoma (CCOC) and sclerosing odontogenic carcinoma (SOC) are rare odontogenic malignancies. Here, we report a case of maxillary CCOC whose clinical and histologic features resembled those of SOC. Radiologically, the tumor presented as an ill-defined, expansile radiolucency with local bone destruction. Histologically, the tumor was comprised of thin cords or strands of odontogenic epithelium permeating through a sclerosed fibrous stroma with occasional clear cell foci. It damaged the cortical plates and invaded the adjacent soft tissue. Immunohistochemical expression of Pancytokeratin, Cytokeratin 19, p63, Cytokeratin 5/6, and Cytokeratin 14, as well as focal expression of Cytokeratin 7, demonstrated the epithelial nature of the tumor. Alcian Blue Periodic acid Schiff staining revealed a lack of intracellular mucin. Fluorescence in situ hybridization analysis revealed Ewing sarcoma RNA binding protein 1 and activating transcription factor 1 gene translocation, further confirming the diagnosis of CCOC. Lastly, we contextualized the genetic analysis of our case to that of CCOC in the literature.
摘要：
透明细胞牙源性癌（CCOC）和硬化性牙源性癌（SOC）都是罕见的牙源性恶性肿瘤。这里,我们报告了一例上颌CCOC，其临床和组织学特征与SOC相似。放射学上,肿瘤表现为不明确的，具有局部骨破坏的可膨胀的放射不透性。组织学上,肿瘤由牙源性上皮的细索或细链组成，通过硬化的纤维基质渗透，偶尔有透明的细胞灶。它损坏了皮质板并侵入了邻近的软组织。全细胞角蛋白的免疫组织化学表达，细胞角蛋白19，p63，细胞角蛋白5/6和细胞角蛋白14以及细胞角蛋白7的局部表达证明了肿瘤的上皮性质。Alcian蓝高碘酸希夫染色显示缺乏细胞内粘蛋白。荧光原位杂交分析显示尤文肉瘤RNA结合蛋白1和激活转录因子1基因易位,进一步确认CCOC的诊断。最后,我们将我们病例的遗传分析与文献中的CCOC进行了语境化。
