Abstract：
A marine antifouling compound, N-octyl-2-hydroxybenzamide (OHBA), inspired by ceramide and paeonol molecules, was created. First, methyl salicylate was synthesized with salicylic acid and methanol, followed by n-octylamine through an ester-amine condensation reaction. Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and mass spectrometry confirmed the characteristic structure of the OHBA compound. Bioassays showed that OHBA inhibits the growth of typical marine fouling organisms, such as Vibrio azureus, Navicula subminuscula, Ulva pertusa, Mytilus edulis, and Amphibalanus amphitrite, indicating its broad-spectrum antifouling ability. A one-year marine real-sea test further demonstrated the excellent antifouling properties of OHBA. OHBA is also extremely biodegradable, with a half-life of 6.3 days, making it a less environmentally harmful replacement for widely-used heavy metal-containing antifoulants.
摘要：
一种海洋防污化合物，N-辛基-2-羟基苯甲酰胺(OHBA),灵感来自神经酰胺和丹皮酚分子，被创造了。首先,以水杨酸和甲醇为原料合成了水杨酸甲酯,然后是正辛胺通过酯-胺缩合反应。傅里叶变换红外光谱,核磁共振波谱,和质谱证实了OHBA化合物的特征结构。生物测定表明，OHBA抑制典型海洋污损生物的生长，如弧菌，Naviculasubminuscula,Ulvapertusa,Mytilusedulis,和两栖动物，表明其具有广谱的防污能力。为期一年的海洋实海试验进一步证明了OHBA的优异防污性能。OHBA也是极其可生物降解的，半衰期为6.3天，使其成为广泛使用的含重金属的防污剂的环境危害较小的替代品。
