METHODS: In this study, a combination of MeSH and free terms for (dried blood spot*[title/abstract])AND (\"Drug Monitoring\"[Mesh])AND(home OR venous)was surveyed using EMBASE, PubMed, Cochrane Library, and Web of Science upon gathering published. we registered this study protocol with the International Prospective Registry of Systematic Reviews (CRD42021247559).
RESULTS: Approximately half (35/75) of the evaluations reported good agreement between DBS and plasma, and the results for drugs with poor agreement may be improved using a haematocrit-based physiological equation. The yield and adherence to home-based DBS exceeded 87%, and questionnaire-based preference for DBS was 77%.
CONCLUSIONS: DBS may be a reliable and feasible home sampling method; however, it requires intricate design and evaluation before implementation.
方法:在本研究中,使用EMBASE调查了MeSH和免费术语(干血斑*[标题/摘要])和(“药物监测”[网格])和(家庭或静脉)的组合,PubMed,科克伦图书馆,和WebofScience在聚会上发表。我们在国际前瞻性系统评价登记处(CRD42021247559)注册了本研究方案.
结果:大约一半(35/75)的评估报告了DBS和血浆之间的良好一致性,使用基于血细胞比容的生理方程可以改善一致性差的药物的结果。以家庭为基础的DBS的收益率和依从性超过87%,基于问卷的DBS偏好为77%。
结论:DBS可能是一种可靠可行的家庭抽样方法;但是,在实施之前,它需要复杂的设计和评估。