Abstract：
Since May 2022, an outbreak of Mpox in non-endemic countries has become a potential public health threat. The objective of this rapid review was to examine the risk profile and modes of transmission of Mpox. PubMed, Web of Science, and Scopus were searched from inception through July 30 to collect case reports/series on patients with Mpox infection. For meta-analysis, data on the total number of participants and deaths by binary categories of exposure (age, sex, country, other co-infections or existing conditions, and mode of contagion) were used. A total of 62 studies (4659 cases) were included. Most cases came from Africa (84.3%), followed by Europe (13.9%). In 63.6% of the cases, the mode of contagion was human contact, while 22.8% of the cases were by animal contact, and 13.5% were unknown or not reported. The mortality rate was 6.5% throughout these studies. The risk of mortality was higher in the younger age group (risk difference: 0.19; 95% CI: 0.02-0.36), in cases with other co-infections or current chronic conditions (risk difference: 0.03; 95% CI: 0.01-0.05) and in the category of low- and middle-income countries (risk difference: 0.06; 95% CI: 0.05-0.08). There were no significant differences with respect to sex or mode of contagion. These results help to understand the major infection pathways and mortality risk profiles of Mpox and underscores the importance of preventing outbreaks in specific settings, especially in settings densely populated by children, such as day care centres and schools.
摘要：
自2022年5月以来，在非流行国家爆发猴痘已成为潜在的公共卫生威胁。这项快速审查的目的是检查猴痘的风险状况和传播方式。PubMed,WebofScience,和Scopus从开始到7月30日进行搜索，以收集有关猴痘感染患者的病例报告/系列。对于荟萃分析，按二元暴露类别划分的参与者总数和死亡数据(年龄，性别,国家,其他共同感染或现有疾病，和传染方式)被使用。共纳入62项研究（4659例）。大多数病例来自非洲（84.3%），其次是欧洲（13.9%）。在63.6%的病例中，传染的方式是人类接触，而22.8%的病例是动物接触，13.5%未知或未报告.在这些研究中死亡率为6.5%。年轻年龄组的死亡风险较高（风险差异：0.19;95％CI：0.02-0.36），在其他合并感染或当前慢性病的情况下（风险差异：0.03;95％CI：0.01-0.05）以及低收入和中等收入国家类别（风险差异：0.06;95％CI：0.05-0.08）。在性别或传染方式方面没有显着差异。这些结果有助于了解猴痘的主要感染途径和死亡风险，并强调了在特定环境中预防疫情爆发的重要性。尤其是在儿童密集的环境中，如日托中心和学校。
