PDF(Pubmed)
Abstract：
In vitro models of liver (patho)physiology, new technologies, and experimental approaches are progressing rapidly. Based on cell lines, induced pluripotent stem cells or primary cells derived from mouse or human liver as well as whole tissue (slices), such in vitro single- and multicellular models, including complex microfluidic organ-on-a-chip systems, provide tools to functionally understand mechanisms of liver health and disease. The International Society of Hepatic Sinusoidal Research (ISHSR) commissioned this working group to review the currently available in vitro liver models and describe the advantages and disadvantages of each in the context of evaluating their use for the study of liver functionality, disease modeling, therapeutic discovery, and clinical applicability.
摘要：
肝脏（病理）生理学的体外模型，新技术,实验方法进展迅速。基于细胞系，诱导多能干细胞或来自小鼠或人类肝脏的原代细胞以及整个组织（切片），这样的体外单细胞和多细胞模型，包括复杂的微流控器官芯片系统，提供工具，从功能上了解肝脏健康和疾病的机制。国际肝窦研究学会委托该工作组审查目前可用的体外肝脏模型，并在评估其用于肝功能研究的背景下描述每种模型的优缺点。疾病建模,治疗性发现,和临床适用性。
