METHODS: In this single-center study, we enrolled participants aged ≥ 20 years undergoing at least two regular health check-ups from 2009 to 2019 at MJ Healthcare Center in Beijing. Each health check-up included physical examination, biochemical tests, a pulmonary function test, a questionnaire. A total of 11,107 adults were included, and cross-sectional and longitudinal analyses were performed.
RESULTS: We found that both prediabetic and diabetic adults had lower lung function than the normal population at baseline, indicating that lung function decline may start from prediabetic status. Quantitatively, with 1-mmol/L increase in fasting plasma glucose level, the forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FVC% and FEV1% lowered by 25 ml, 13 ml, 0.71-1.03%, and 0.46-0.72%, respectively. However, no significant difference was found in the rates for the lung function decline among different baseline diabetes statuses.
CONCLUSIONS: People with higher blood glucose level had more severe lung function decline, with decline starting from prediabetic status, but no significant difference was noted in the rate of lung function decline based on different baseline diabetic statuses.
方法:在这项单中心研究中,我们纳入了年龄≥20岁的参与者,这些参与者从2009年至2019年在北京MJHealthcareCenter接受了至少两次常规健康检查.每次健康检查包括体检,生化试验,肺功能测试,一份问卷。总共包括11,107名成年人,并进行了横截面和纵向分析。
结果:我们发现糖尿病前期和糖尿病成人在基线时的肺功能均低于正常人群,表明肺功能下降可能始于糖尿病前期状态。定量地,随着空腹血糖水平增加1-mmol/L,强制肺活量(FVC),1s用力呼气容积(FEV1),FVC%和FEV1%降低25ml,13毫升,0.71-1.03%,和0.46-0.72%,分别。然而,在不同的糖尿病基线状态之间,肺功能下降率无显著差异.
结论:血糖水平较高的人肺功能下降更严重,从糖尿病前期开始下降,但基于不同的基线糖尿病状态,肺功能下降率无显著差异.