PDF(Pubmed)
Abstract：
UNASSIGNED: We conducted a retrospective cohort study on COVID-19 patients with and without dementia by extracting data from the HCA Healthcare Enterprise Data Warehouse between January-September 2020.
UNASSIGNED: To describe the role of patients\' baseline characteristics specifically dementia in determining overall health outcomes in COVID-19 patients.
UNASSIGNED: We grouped in-patients who had ICD-10 codes for dementia (DM) with age and gender-matched (1:2) patients without dementia (ND). Our primary outcome variables were in-hospital mortality, length of stay, Intensive Care Unit (ICU) admission, ICU-free days, mechanical ventilation (MV) use, MV-free days and 90-day re-admission.
UNASSIGNED: Matching provided similar age and sex in DM and ND groups. BMI (median, 25.8 vs. 27.6) and proportion of patients who had smoked (23.3 vs. 31.3%) were lower in DM than in ND patients. The median (IQR) Elixhauser Comorbidity Index was higher in dementia patients 7 (5-10) vs. 5 (3-7, p < 0.01). Higher mortality was observed in DM group (30.8%) vs. ND group (26.4%, p < 0.01) as an unadjusted univariate analysis. The 90-day readmission was not different (32.1 vs. 31.8%, p = 0.8). In logistic regression analysis, the odds of dying were not different between patients in DM and ND groups (OR = 1.0; 95% CI 0.86-1.17), but the odds of ICU admissions were significantly lower for dementia patients (OR = 0.58, 95% CI 0.51-0.66).
UNASSIGNED: Our data showed that COVID-19 patients with dementia did not fare substantially worse, but in fact, fared better when certain metrics were considered.
UNASSIGNED: To describe the role of patients\' baseline characteristics specifically dementia in determining overall health outcomes in COVID-19 patients.
UNASSIGNED: We grouped in-patients who had ICD-10 codes for dementia (DM) with age and gender-matched (1:2) patients without dementia (ND). Our primary outcome variables were in-hospital mortality, length of stay, Intensive Care Unit (ICU) admission, ICU-free days, mechanical ventilation (MV) use, MV-free days and 90-day re-admission.
UNASSIGNED: Matching provided similar age and sex in DM and ND groups. BMI (median, 25.8 vs. 27.6) and proportion of patients who had smoked (23.3 vs. 31.3%) were lower in DM than in ND patients. The median (IQR) Elixhauser Comorbidity Index was higher in dementia patients 7 (5-10) vs. 5 (3-7, p < 0.01). Higher mortality was observed in DM group (30.8%) vs. ND group (26.4%, p < 0.01) as an unadjusted univariate analysis. The 90-day readmission was not different (32.1 vs. 31.8%, p = 0.8). In logistic regression analysis, the odds of dying were not different between patients in DM and ND groups (OR = 1.0; 95% CI 0.86-1.17), but the odds of ICU admissions were significantly lower for dementia patients (OR = 0.58, 95% CI 0.51-0.66).
UNASSIGNED: Our data showed that COVID-19 patients with dementia did not fare substantially worse, but in fact, fared better when certain metrics were considered.
摘要：
未经评估：我们在2020年1月至9月之间从HCA医疗保健企业数据仓库中提取数据，对患有和不患有痴呆症的COVID-19患者进行了一项回顾性队列研究。
未经评估：描述患者的基线特征，特别是痴呆在确定COVID-19患者整体健康结局中的作用。
UNASSIGNED：我们将患有痴呆（DM）ICD-10编码的住院患者与年龄和性别匹配（1：2）的无痴呆（ND）患者分组。我们的主要结果变量是住院死亡率，逗留时间,重症监护病房（ICU）入院，无ICU天数,机械通气（MV）的使用，无MV日和90天重新入场。
UNASSIGNED：匹配在DM和ND组中提供了相似的年龄和性别。BMI（中位数，25.8vs.27.6)和吸烟患者的比例(23.3vs.31.3％）DM患者低于ND患者。痴呆症患者的中位数（IQR）Elixhauser合并症指数高于7（5-10）。5(3-7,p<0.01)。在DM组中观察到更高的死亡率（30.8％）与ND组（26.4%，p<0.01)作为未调整的单变量分析。90天的再入院没有什么不同（32.1与31.8%,p=0.8)。在逻辑回归分析中，DM组和ND组患者的死亡几率没有差异(OR=1.0;95%CI0.86-1.17),但痴呆患者入住ICU的几率显著较低(OR=0.58,95%CI0.51-0.66).
未经评估：我们的数据显示，COVID-19痴呆症患者的情况并没有明显恶化，但事实上,当考虑某些指标时，情况会更好。
未经评估：描述患者的基线特征，特别是痴呆在确定COVID-19患者整体健康结局中的作用。
UNASSIGNED：我们将患有痴呆（DM）ICD-10编码的住院患者与年龄和性别匹配（1：2）的无痴呆（ND）患者分组。我们的主要结果变量是住院死亡率，逗留时间,重症监护病房（ICU）入院，无ICU天数,机械通气（MV）的使用，无MV日和90天重新入场。
UNASSIGNED：匹配在DM和ND组中提供了相似的年龄和性别。BMI（中位数，25.8vs.27.6)和吸烟患者的比例(23.3vs.31.3％）DM患者低于ND患者。痴呆症患者的中位数（IQR）Elixhauser合并症指数高于7（5-10）。5(3-7,p<0.01)。在DM组中观察到更高的死亡率（30.8％）与ND组（26.4%，p<0.01)作为未调整的单变量分析。90天的再入院没有什么不同（32.1与31.8%,p=0.8)。在逻辑回归分析中，DM组和ND组患者的死亡几率没有差异(OR=1.0;95%CI0.86-1.17),但痴呆患者入住ICU的几率显著较低(OR=0.58,95%CI0.51-0.66).
未经评估：我们的数据显示，COVID-19痴呆症患者的情况并没有明显恶化，但事实上,当考虑某些指标时，情况会更好。
