Abstract：
BACKGROUND: Systemic sclerosis (SSc) is an incurable autoimmune disease characterized by progressive skin fibrosis and organ failure. Tenosynovitis is a common musculoskeletal manifestation, but tendon rupture has seldom reported in SSc.
METHODS: We present a rare case of a 49-year-old female with SSc who has suffered from bilateral tendon rupture of the fourth and fifth digits with positive antinuclear antibody (ANA) and anti-centromere B antibody, but negative rheumatoid factor in serum. In the extensor tendons of the patient\'s hands, inflammation, edema, hypertrophy and tendon interruption were detected with ultrasound and magnetic resonance imaging(MRI). Tendon transfer repair surgery was performed and 10 mg/week methotrexate was then used in this patient. Her hand function was improved well with methotrexate and rehabilitation treatment postoperatively.
CONCLUSIONS: Early detection of tenosynovitis is necessary to prevent tendon rupture in SSc patients. Ultrasound and Magnetic Resonance Imaging appear to be useful examinations for evaluating tendon pathology for early detection.
METHODS: We present a rare case of a 49-year-old female with SSc who has suffered from bilateral tendon rupture of the fourth and fifth digits with positive antinuclear antibody (ANA) and anti-centromere B antibody, but negative rheumatoid factor in serum. In the extensor tendons of the patient\'s hands, inflammation, edema, hypertrophy and tendon interruption were detected with ultrasound and magnetic resonance imaging(MRI). Tendon transfer repair surgery was performed and 10 mg/week methotrexate was then used in this patient. Her hand function was improved well with methotrexate and rehabilitation treatment postoperatively.
CONCLUSIONS: Early detection of tenosynovitis is necessary to prevent tendon rupture in SSc patients. Ultrasound and Magnetic Resonance Imaging appear to be useful examinations for evaluating tendon pathology for early detection.
摘要：
背景：系统性硬化症（SSc）是一种无法治愈的自身免疫性疾病，其特征是进行性皮肤纤维化和器官衰竭。腱鞘炎是一种常见的肌肉骨骼表现，但在SSc中很少报道肌腱断裂。
方法：我们介绍了一例罕见的49岁女性SSc患者，该患者患有双侧四指和五指肌腱断裂，抗核抗体（ANA）和抗着丝粒B抗体阳性，但血清中类风湿因子呈阴性。在病人手的伸肌腱中，炎症,水肿,使用超声和磁共振成像（MRI）检测到肥大和肌腱中断。进行肌腱转移修复手术，然后在该患者中使用10mg/周的甲氨蝶呤。术后甲氨蝶呤和康复治疗使她的手功能得到了很好的改善。
结论：早期发现腱鞘炎对预防SSc患者肌腱断裂是必要的。超声和磁共振成像似乎是评估肌腱病理以进行早期检测的有用检查。
方法：我们介绍了一例罕见的49岁女性SSc患者，该患者患有双侧四指和五指肌腱断裂，抗核抗体（ANA）和抗着丝粒B抗体阳性，但血清中类风湿因子呈阴性。在病人手的伸肌腱中，炎症,水肿,使用超声和磁共振成像（MRI）检测到肥大和肌腱中断。进行肌腱转移修复手术，然后在该患者中使用10mg/周的甲氨蝶呤。术后甲氨蝶呤和康复治疗使她的手功能得到了很好的改善。
结论：早期发现腱鞘炎对预防SSc患者肌腱断裂是必要的。超声和磁共振成像似乎是评估肌腱病理以进行早期检测的有用检查。
