PDF(Pubmed)
Abstract：
In cystic fibrosis (CF) patients, Gram-negative Burkholderia cepacia complex (Bcc) infections are associated with recurrent pulmonary exacerbations. Bcc organisms are innately resistant to many antibiotics, and infection with B. cenocepacia is a contraindication to lung transplantation. We report a CF patient with severe lung disease, colonized with Bcc, with a history of around nine exacerbations per year for over 10 years, for whom antibiotic regimens (including targeted and broad-spectrum antibiotics) had not cleared infection or extended the interval between exacerbations. After receiving a 2 week cefiderocol-containing regimen, the patient remained stable for more than 5 months without the need for additional antibiotics or hospital admissions for respiratory exacerbations.
摘要：
在囊性纤维化（CF）患者中，革兰氏阴性洋葱伯克霍尔德氏菌（Bcc）感染与复发性肺加重有关。Bcc生物天生对许多抗生素有抗药性，而隐孢子虫感染是肺移植的禁忌症。我们报告了一名患有严重肺部疾病的CF患者，被密送所定居,在过去的10年里，每年大约有9次恶化的历史，抗生素治疗方案(包括靶向和广谱抗生素)未清除感染或延长加重间隔时间.在接受含有头孢地洛的2周方案后，患者保持稳定超过5个月,无需额外使用抗生素或因呼吸加重而入院.
