Abstract：
Singapore surrendered to the Japanese invasion in February 1942 after its water supply collapsed. At the suggestion of the colonial medical authorities, an emergency typhoid immunisation campaign was then begun using locally manufactured vaccine from extemporary materials; within 3 months, >600 000 had been immunised. Comparison with prewar statistics suggests that a postsurrender typhoid fever epidemic was prevented despite an increase in other enteric infections. Public health crises with disrupted supply chains may make locally manufactured vaccines of increasing importance in the future.
摘要：
1942年2月，新加坡在供水崩溃后向日本投降。根据殖民地医疗当局的建议，随后，开始了一项紧急伤寒免疫运动，使用当地制造的非暂时性材料疫苗；在3个月内，>60000已经免疫。与战前统计数据的比较表明，尽管其他肠道感染有所增加，但预防了投降后的伤寒流行。供应链中断的公共卫生危机可能使当地生产的疫苗在未来变得越来越重要。
