Abstract：
OBJECTIVE: This study aimed to determine the possible relationship between periodontal disease and ankylosing spondylitis (AS) by evaluating clinical periodontal measurements and gingival crevicular fluid (GCF) levels of sclerostin, interleukin-1β (IL-1ß), and matrix metalloproteinase-8 (MMP-8) levels.
METHODS: Twenty-eight patients with AS (AS group) and 28 systemically healthy controls (C group) were enrolled in this study. Full-mouth periodontal measurements: plaque index, bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL) measurements were obtained from all patients. AS-related parameters were included in the data analyses. An enzyme-linked immunosorbent assay determined GCF IL-1β, MMP-8, and sclerostin levels.
RESULTS: There were no significant differences in the clinical periodontal measurements between the two groups (p > 0.05). Interestingly, patients with AS had significantly lower GCF sclerostin levels than the C group (p < 0.05). But there were no statistical differences in the GCF levels of IL-1ß and MMP-8 between the two groups (p > 0.05). Serum C-reactive protein (CRP) levels strongly correlated with both BOP (r = 0.497, p < 0.05) and PPD (r = 0.570, p < 0.05) in the AS group. Bath AS Metrology Index (BASMI) also positively correlated with both BOP (r = 0.530, p < 0.05) and CAL (r = 0.568, p < 0.05). Similarly, Maastrıcht Ankylosing Spondylitis Enthesis Score (MASES) strongly correlated with both BOP (r = 0.487, p < 0.05) and CAL (r = 0.522, p < 0.05).
CONCLUSIONS: These results suggest that the patient\'s systemic condition may influence local sclerostin levels in GCF, and the strong correlations between periodontal measurements and AS-related parameters may indicate an interrelationship between inflammatory periodontal disease and AS.
CONCLUSIONS: The present study provides important information concerning the relationship between periodontal disease and ankylosing spondylitis.
BACKGROUND: Thai Clinical Trials.gov (TCTR20200908001) (08. September 2020).
METHODS: Twenty-eight patients with AS (AS group) and 28 systemically healthy controls (C group) were enrolled in this study. Full-mouth periodontal measurements: plaque index, bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL) measurements were obtained from all patients. AS-related parameters were included in the data analyses. An enzyme-linked immunosorbent assay determined GCF IL-1β, MMP-8, and sclerostin levels.
RESULTS: There were no significant differences in the clinical periodontal measurements between the two groups (p > 0.05). Interestingly, patients with AS had significantly lower GCF sclerostin levels than the C group (p < 0.05). But there were no statistical differences in the GCF levels of IL-1ß and MMP-8 between the two groups (p > 0.05). Serum C-reactive protein (CRP) levels strongly correlated with both BOP (r = 0.497, p < 0.05) and PPD (r = 0.570, p < 0.05) in the AS group. Bath AS Metrology Index (BASMI) also positively correlated with both BOP (r = 0.530, p < 0.05) and CAL (r = 0.568, p < 0.05). Similarly, Maastrıcht Ankylosing Spondylitis Enthesis Score (MASES) strongly correlated with both BOP (r = 0.487, p < 0.05) and CAL (r = 0.522, p < 0.05).
CONCLUSIONS: These results suggest that the patient\'s systemic condition may influence local sclerostin levels in GCF, and the strong correlations between periodontal measurements and AS-related parameters may indicate an interrelationship between inflammatory periodontal disease and AS.
CONCLUSIONS: The present study provides important information concerning the relationship between periodontal disease and ankylosing spondylitis.
BACKGROUND: Thai Clinical Trials.gov (TCTR20200908001) (08. September 2020).
摘要：
目的：本研究旨在通过评估临床牙周测量和龈沟液（GCF）硬化蛋白水平，确定牙周病与强直性脊柱炎（AS）之间的可能关系，白细胞介素-1β（IL-1β），和基质金属蛋白酶-8（MMP-8）水平。
方法：本研究纳入了28例AS患者（AS组）和28例全身健康对照（C组）。全口牙周测量：菌斑指数，探查出血(BOP),探测袋深度（PPD），从所有患者获得临床依恋水平(CAL)测量值。AS相关参数包括在数据分析中。酶联免疫吸附测定GCFIL-1β，MMP-8和硬化蛋白水平。
结果：两组的临床牙周测量结果无显著差异（p>0.05）。有趣的是,AS患者的GCF硬化蛋白水平明显低于C组（p<0.05）。但两组GCF中IL-1β和MMP-8水平差异无统计学意义(p>0.05)。AS组血清C反应蛋白(CRP)水平与BOP(r=0.497,p<0.05)和PPD(r=0.570,p<0.05)均有显著相关性。BathAS计量学指数（BASMI）也与BOP（r=0.530，p<0.05）和CAL（r=0.568，p<0.05）呈正相关。同样，Mastratdicht强直性脊柱炎的发生评分（MASES）与BOP（r=0.487，p<0.05）和CAL（r=0.522，p<0.05）均密切相关。
结论：这些结果表明，患者的全身状况可能会影响GCF中的局部硬化素水平，牙周测量值与AS相关参数之间的强相关性可能表明炎症性牙周病与AS之间存在相互关系。
结论：本研究提供了有关牙周病与强直性脊柱炎之间关系的重要信息。
背景：泰国临床试验.gov（TCTR20200908001）（08。2020年9月）。
方法：本研究纳入了28例AS患者（AS组）和28例全身健康对照（C组）。全口牙周测量：菌斑指数，探查出血(BOP),探测袋深度（PPD），从所有患者获得临床依恋水平(CAL)测量值。AS相关参数包括在数据分析中。酶联免疫吸附测定GCFIL-1β，MMP-8和硬化蛋白水平。
结果：两组的临床牙周测量结果无显著差异（p>0.05）。有趣的是,AS患者的GCF硬化蛋白水平明显低于C组（p<0.05）。但两组GCF中IL-1β和MMP-8水平差异无统计学意义(p>0.05)。AS组血清C反应蛋白(CRP)水平与BOP(r=0.497,p<0.05)和PPD(r=0.570,p<0.05)均有显著相关性。BathAS计量学指数（BASMI）也与BOP（r=0.530，p<0.05）和CAL（r=0.568，p<0.05）呈正相关。同样，Mastratdicht强直性脊柱炎的发生评分（MASES）与BOP（r=0.487，p<0.05）和CAL（r=0.522，p<0.05）均密切相关。
结论：这些结果表明，患者的全身状况可能会影响GCF中的局部硬化素水平，牙周测量值与AS相关参数之间的强相关性可能表明炎症性牙周病与AS之间存在相互关系。
结论：本研究提供了有关牙周病与强直性脊柱炎之间关系的重要信息。
背景：泰国临床试验.gov（TCTR20200908001）（08。2020年9月）。
