%0 Journal Article
%T Evaluating the relationship between ankylosing spondylitis and periodontal disease: a case-control study.
%A Daltaban Ö
%A Enginar AÜ
%A Üstün K
%A Hatipoğlu M
%A Kaçar C
%A Tuncer T
%J Clin Oral Investig
%V 27
%N 1
%D Jan 2023
%M 36394610
%F 3.606
%R 10.1007/s00784-022-04776-4
%X <B>OBJECTIVE: </B>This study aimed to determine the possible relationship between periodontal disease and ankylosing spondylitis (AS) by evaluating clinical periodontal measurements and gingival crevicular fluid (GCF) levels of sclerostin, interleukin-1β (IL-1ß), and matrix metalloproteinase-8 (MMP-8) levels.<BR><B>METHODS: </B>Twenty-eight patients with AS (AS group) and 28 systemically healthy controls (C group) were enrolled in this study. Full-mouth periodontal measurements: plaque index, bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL) measurements were obtained from all patients. AS-related parameters were included in the data analyses. An enzyme-linked immunosorbent assay determined GCF IL-1β, MMP-8, and sclerostin levels.<BR><B>RESULTS: </B>There were no significant differences in the clinical periodontal measurements between the two groups (p > 0.05). Interestingly, patients with AS had significantly lower GCF sclerostin levels than the C group (p < 0.05). But there were no statistical differences in the GCF levels of IL-1ß and MMP-8 between the two groups (p > 0.05). Serum C-reactive protein (CRP) levels strongly correlated with both BOP (r = 0.497, p < 0.05) and PPD (r = 0.570, p < 0.05) in the AS group. Bath AS Metrology Index (BASMI) also positively correlated with both BOP (r = 0.530, p < 0.05) and CAL (r = 0.568, p < 0.05). Similarly, Maastrıcht Ankylosing Spondylitis Enthesis Score (MASES) strongly correlated with both BOP (r = 0.487, p < 0.05) and CAL (r = 0.522, p < 0.05).<BR><B>CONCLUSIONS: </B>These results suggest that the patient's systemic condition may influence local sclerostin levels in GCF, and the strong correlations between periodontal measurements and AS-related parameters may indicate an interrelationship between inflammatory periodontal disease and AS.<BR><B>CONCLUSIONS: </B>The present study provides important information concerning the relationship between periodontal disease and ankylosing spondylitis.<BR><B>BACKGROUND: </B>Thai Clinical Trials.gov (TCTR20200908001) (08. September 2020).