PDF(Pubmed)
Abstract：
The relevance of protein-glycan interactions in immunity has long been underestimated. Yet, the immune system possesses numerous classes of glycan-binding proteins, so-called lectins. Of specific interest is the group of myeloid C-type lectin receptors (CLRs) as they are mainly expressed by myeloid cells and play an important role in the initiation of an immune response. Myeloid CLRs represent a major group amongst pattern recognition receptors (PRRs), placing them at the center of the rapidly growing field of glycoimmunology. CLRs have evolved to encompass a wide range of structures and functions and to recognize a large number of glycans and many other ligands from different classes of biopolymers. This review aims at providing the reader with an overview of myeloid CLRs and selected ligands, while highlighting recent insights into CLR-ligand interactions. Subsequently, methodological approaches in CLR-ligand research will be presented. Finally, this review will discuss how CLR-ligand interactions culminate in immunological functions, how glycan mimicry favors immune escape by pathogens, and in which way immune responses can be affected by CLR-ligand interactions in the long term.
摘要：
长期以来，人们一直低估了蛋白质-聚糖相互作用在免疫中的相关性。然而，免疫系统拥有许多种类的聚糖结合蛋白，所谓的凝集素。特别感兴趣的是一组髓样C型凝集素受体(CLR),因为它们主要由髓样细胞表达并且在免疫应答的起始中起重要作用。髓样CLR代表模式识别受体（PRR）中的一个主要群体，将它们置于快速增长的糖免疫学领域的中心。CLR已经发展为涵盖宽范围的结构和功能并且识别来自不同类别的生物聚合物的大量聚糖和许多其他配体。这篇综述旨在为读者提供髓样CLR和选定的配体的概述，同时强调最近对CLR-配体相互作用的见解。随后，将介绍CLR-配体研究的方法学方法。最后,这篇综述将讨论CLR-配体相互作用如何在免疫功能中达到顶峰，聚糖模仿如何促进病原体的免疫逃逸，免疫反应可以长期受到CLR-配体相互作用的影响。
