Abstract：
UNASSIGNED: The basis of good vocal outcomes following Transoral Laser Microlaryngeal Cordectomy (TLMC) is the narrow margin that is oncologically accepted for the glottis. Our objective is to evaluate the reliability of frozen section (FS) compared to paraffin section (PS) during TLMC and during laser laryngeal surgery when an incisonal or excisional biopsy is being performed.
UNASSIGNED: Retrospectively, records of 159 sequential patients who underwent CO2 laser laryngeal surgery with intraoperative FS were reviewed along with the final PS. Group A patients were TLMC patients where FS was utilized for free margin confirmation (42 specimens) and Group B patients were those in whom FS was performed for primary diagnosis (122 specimens).
UNASSIGNED: A total of 164 samples were included where specimens submitted for FS were also processed for PS. Concordance was observed in 156 samples, discordance in 8, with 4 cases belonging to each group. FS was reported as false negative in 5 and false positive in 3 cases. In Group A where FS was utilized for free margin confirmation, the sensitivity was found to be 60%, specificity and positive predictive value (PPV) 100%, and negative predictive value (NPV) 88.9%. In Group B where FS was performed for primary diagnosis, the sensitivity was found to be 98.4%, specificity 95.1%, PPV 95.2%, and NPV 98.3%.
UNASSIGNED: A 100% PPV of FS in group A suggests that positive FS margins during TLMC may be safely relied upon in making decisions to upgrade the type of cordectomy being performed. A NPV of 88.9% in group A suggests that despite a clear frozen margin report during TLMC, 11.1% of patients would need further treatment. A PPV of 95.2% in group B suggests that although FS analysis is important for guiding further management, decisions regarding major laryngeal surgery should not be undertaken based solely on FS.
UNASSIGNED: Retrospectively, records of 159 sequential patients who underwent CO2 laser laryngeal surgery with intraoperative FS were reviewed along with the final PS. Group A patients were TLMC patients where FS was utilized for free margin confirmation (42 specimens) and Group B patients were those in whom FS was performed for primary diagnosis (122 specimens).
UNASSIGNED: A total of 164 samples were included where specimens submitted for FS were also processed for PS. Concordance was observed in 156 samples, discordance in 8, with 4 cases belonging to each group. FS was reported as false negative in 5 and false positive in 3 cases. In Group A where FS was utilized for free margin confirmation, the sensitivity was found to be 60%, specificity and positive predictive value (PPV) 100%, and negative predictive value (NPV) 88.9%. In Group B where FS was performed for primary diagnosis, the sensitivity was found to be 98.4%, specificity 95.1%, PPV 95.2%, and NPV 98.3%.
UNASSIGNED: A 100% PPV of FS in group A suggests that positive FS margins during TLMC may be safely relied upon in making decisions to upgrade the type of cordectomy being performed. A NPV of 88.9% in group A suggests that despite a clear frozen margin report during TLMC, 11.1% of patients would need further treatment. A PPV of 95.2% in group B suggests that although FS analysis is important for guiding further management, decisions regarding major laryngeal surgery should not be undertaken based solely on FS.
摘要：
未经证实：经口激光喉喉声带切除术（TLMC）后良好声带结果的基础是声门在肿瘤学上接受的狭窄边缘。我们的目标是评估TLMC期间和激光喉手术期间进行切开或切除活检时，冷冻切片（FS）与石蜡切片（PS）相比的可靠性。
未经评估：回顾，我们回顾了159例接受CO2激光喉部手术术中FS的序贯患者的记录以及最终PS.A组患者为TLMC患者，其中FS用于自由边缘确认（42个标本），B组患者为进行FS用于主要诊断的患者（122个标本）。
UNASSIGNED：总共包括164个样本，其中提交FS的样本也进行了PS处理。在156个样品中观察到一致性，不一致8例，每组4例。FS报告为假阴性5例，假阳性3例。在A组中，FS用于自由保证金确认，灵敏度为60%，特异性和阳性预测值(PPV)100%，阴性预测值（NPV）为88.9%。B组主要诊断为FS,灵敏度为98.4%，特异性95.1%，PPV95.2%,和净现值98.3%。
UNASSIGNED：A组FS的100%PPV表明，TLMC期间的阳性FS边缘可以安全地决定升级正在进行的子宫内膜切除术类型。A组的NPV为88.9%，表明尽管TLMC期间有明确的冻结利润报告，11.1%的患者需要进一步治疗。B组的PPV为95.2%，表明尽管FS分析对于指导进一步的管理很重要，有关喉部大手术的决定不应仅基于FS.
未经评估：回顾，我们回顾了159例接受CO2激光喉部手术术中FS的序贯患者的记录以及最终PS.A组患者为TLMC患者，其中FS用于自由边缘确认（42个标本），B组患者为进行FS用于主要诊断的患者（122个标本）。
UNASSIGNED：总共包括164个样本，其中提交FS的样本也进行了PS处理。在156个样品中观察到一致性，不一致8例，每组4例。FS报告为假阴性5例，假阳性3例。在A组中，FS用于自由保证金确认，灵敏度为60%，特异性和阳性预测值(PPV)100%，阴性预测值（NPV）为88.9%。B组主要诊断为FS,灵敏度为98.4%，特异性95.1%，PPV95.2%,和净现值98.3%。
UNASSIGNED：A组FS的100%PPV表明，TLMC期间的阳性FS边缘可以安全地决定升级正在进行的子宫内膜切除术类型。A组的NPV为88.9%，表明尽管TLMC期间有明确的冻结利润报告，11.1%的患者需要进一步治疗。B组的PPV为95.2%，表明尽管FS分析对于指导进一步的管理很重要，有关喉部大手术的决定不应仅基于FS.
