UNASSIGNED: Retrospectively, records of 159 sequential patients who underwent CO2 laser laryngeal surgery with intraoperative FS were reviewed along with the final PS. Group A patients were TLMC patients where FS was utilized for free margin confirmation (42 specimens) and Group B patients were those in whom FS was performed for primary diagnosis (122 specimens).
UNASSIGNED: A total of 164 samples were included where specimens submitted for FS were also processed for PS. Concordance was observed in 156 samples, discordance in 8, with 4 cases belonging to each group. FS was reported as false negative in 5 and false positive in 3 cases. In Group A where FS was utilized for free margin confirmation, the sensitivity was found to be 60%, specificity and positive predictive value (PPV) 100%, and negative predictive value (NPV) 88.9%. In Group B where FS was performed for primary diagnosis, the sensitivity was found to be 98.4%, specificity 95.1%, PPV 95.2%, and NPV 98.3%.
UNASSIGNED: A 100% PPV of FS in group A suggests that positive FS margins during TLMC may be safely relied upon in making decisions to upgrade the type of cordectomy being performed. A NPV of 88.9% in group A suggests that despite a clear frozen margin report during TLMC, 11.1% of patients would need further treatment. A PPV of 95.2% in group B suggests that although FS analysis is important for guiding further management, decisions regarding major laryngeal surgery should not be undertaken based solely on FS.
未经评估:回顾,我们回顾了159例接受CO2激光喉部手术术中FS的序贯患者的记录以及最终PS.A组患者为TLMC患者,其中FS用于自由边缘确认(42个标本),B组患者为进行FS用于主要诊断的患者(122个标本)。
UNASSIGNED:总共包括164个样本,其中提交FS的样本也进行了PS处理。在156个样品中观察到一致性,不一致8例,每组4例。FS报告为假阴性5例,假阳性3例。在A组中,FS用于自由保证金确认,灵敏度为60%,特异性和阳性预测值(PPV)100%,阴性预测值(NPV)为88.9%。B组主要诊断为FS,灵敏度为98.4%,特异性95.1%,PPV95.2%,和净现值98.3%。
UNASSIGNED:A组FS的100%PPV表明,TLMC期间的阳性FS边缘可以安全地决定升级正在进行的子宫内膜切除术类型。A组的NPV为88.9%,表明尽管TLMC期间有明确的冻结利润报告,11.1%的患者需要进一步治疗。B组的PPV为95.2%,表明尽管FS分析对于指导进一步的管理很重要,有关喉部大手术的决定不应仅基于FS.