Abstract：
When the production of reactive oxygen species (ROS) is overloaded surpassing the capacity of the reductive rheostat, mammalian cells undergo a series of oxidative damage termed oxidative stress (OS). This phenomenon is ubiquitously detected in many human pathological conditions. Wound healing program implicates continuous neovascularization, cell proliferation, and wound remodeling. Increasing evidence indicates that reactive oxygen species (ROS) have profound impacts on the wound healing process through regulating a series of the physiological and pathological program including inflammatory response, cell proliferation, angiogenesis, granulation as well as extracellular matrix formation. In most pathological wound healing processes, excessive ROS exerts a negative role on the wound healing process. Interestingly, the moderate increase of ROS levels is beneficial in killing bacteria at the wound site, which creates a sterile niche for revascularization. In this review, we discussed the physiological rhythms of wound healing and the role of ROS in this progress, aim to explore the potential manipulation of OS as a promising therapeutic avenue.
摘要：
当活性氧（ROS）的产生超负荷超过还原性变阻器的容量时，哺乳动物细胞经历一系列氧化损伤称为氧化应激(OS)。这种现象在许多人类病理状况中普遍存在。伤口愈合程序涉及持续的新生血管形成，细胞增殖，和伤口重塑。越来越多的证据表明，活性氧（ROS）通过调节一系列生理和病理程序，包括炎症反应，对伤口愈合过程产生深远的影响。细胞增殖，血管生成,肉芽以及细胞外基质的形成。在大多数病理性伤口愈合过程中，过量的ROS对伤口愈合过程起着负面作用。有趣的是,ROS水平的适度增加有利于杀死伤口部位的细菌，为血运重建创造了一个无菌的生态位。在这次审查中,我们讨论了伤口愈合的生理节律和ROS在这一进程中的作用，旨在探索OS作为一种有前途的治疗途径的潜在操作。
