Abstract：
UNASSIGNED: St John\'s wort (SJW, Hypericum perforatum) has a long history of medicinal use, mainly for its antidepressive effects and for wound healing. However, to the best of our knowledge, this is the first clinical study evaluating the effects of topical SJW oil macerates on the intractable skin lesions of idiopathic granulomatous mastitis (IGM).
UNASSIGNED: SJW oil massage (twice daily for two minutes) was recommended between 2016 and 2019, only for patients with persistent or intractable skin lesions, after complete regression of granulomatous mass with two cycles of high-dose oral steroid and empiric antibiotics. Skin lesions were assessed and graded, before and after treatment, as clear, mild, moderate and severe. A questionnaire was also completed for each patient at the end of the six-week treatment.
UNASSIGNED: A total of 21 patients with persistent IGM lesions used SJW oil after completion of the standard treatment protocol. All patients were women, and the mean age was 36.6 years. Hyperaemia (100%), scaling (61%), induration (52%) and ulcers (28%) were the predominant skin lesions. Distribution of the lesions according to the degree of severity were graded mild, moderate and severe, and seen in 35%, 41% and 23% of the patients, respectively. When compared with pre-treatment scores, there were very significant regressions (clear: 76.4%, mild: 17.6%, moderate: 3.9%, severe: 1.9%; p<0.001 for each). The overall success rate (total clearance or decrease/decline in lesions) of treatment was 94%.
UNASSIGNED: SJW oil massage seems to be very effective in patients with IGM-related persistent skin lesions.
UNASSIGNED: SJW oil massage (twice daily for two minutes) was recommended between 2016 and 2019, only for patients with persistent or intractable skin lesions, after complete regression of granulomatous mass with two cycles of high-dose oral steroid and empiric antibiotics. Skin lesions were assessed and graded, before and after treatment, as clear, mild, moderate and severe. A questionnaire was also completed for each patient at the end of the six-week treatment.
UNASSIGNED: A total of 21 patients with persistent IGM lesions used SJW oil after completion of the standard treatment protocol. All patients were women, and the mean age was 36.6 years. Hyperaemia (100%), scaling (61%), induration (52%) and ulcers (28%) were the predominant skin lesions. Distribution of the lesions according to the degree of severity were graded mild, moderate and severe, and seen in 35%, 41% and 23% of the patients, respectively. When compared with pre-treatment scores, there were very significant regressions (clear: 76.4%, mild: 17.6%, moderate: 3.9%, severe: 1.9%; p<0.001 for each). The overall success rate (total clearance or decrease/decline in lesions) of treatment was 94%.
UNASSIGNED: SJW oil massage seems to be very effective in patients with IGM-related persistent skin lesions.
摘要：
未经批准：圣约翰草（SJW，贯叶连翘）具有悠久的药用历史，主要用于其抗抑郁作用和伤口愈合。然而,据我们所知,这是第一项评估局部SJW浸油对特发性肉芽肿性乳腺炎(IGM)顽固性皮肤病变影响的临床研究.
UNASSIGNED：建议在2016年至2019年之间进行SJW油按摩（每天两次，持续两分钟），仅适用于持续性或难治性皮肤病变的患者，在使用两个大剂量口服类固醇和经验性抗生素的肉芽肿性肿块完全消退后。对皮肤损伤进行评估和分级，治疗前后,很清楚,温和,中度和重度。在6周治疗结束时,还对每位患者完成问卷。
UNASSIGNED：共有21名患有持续性IGM病变的患者在完成标准治疗方案后使用了SJW油。所有患者都是女性,平均年龄为36.6岁。充血症（100%），缩放比例（61%），硬结（52％）和溃疡（28％）是主要的皮肤病变。病变分布按严重程度分级轻度，中度和重度，在35%中看到，41%和23%的患者，分别。与治疗前的评分相比，有非常显著的回归(明确：76.4%，轻度：17.6%，中等：3.9%，严重：1.9%；每个p<0.001)。治疗的总体成功率（总清除或病变减少/下降）为94％。
UNASSIGNED：SJW油按摩似乎对IGM相关的持续性皮肤病变患者非常有效。
UNASSIGNED：建议在2016年至2019年之间进行SJW油按摩（每天两次，持续两分钟），仅适用于持续性或难治性皮肤病变的患者，在使用两个大剂量口服类固醇和经验性抗生素的肉芽肿性肿块完全消退后。对皮肤损伤进行评估和分级，治疗前后,很清楚,温和,中度和重度。在6周治疗结束时,还对每位患者完成问卷。
UNASSIGNED：共有21名患有持续性IGM病变的患者在完成标准治疗方案后使用了SJW油。所有患者都是女性,平均年龄为36.6岁。充血症（100%），缩放比例（61%），硬结（52％）和溃疡（28％）是主要的皮肤病变。病变分布按严重程度分级轻度，中度和重度，在35%中看到，41%和23%的患者，分别。与治疗前的评分相比，有非常显著的回归(明确：76.4%，轻度：17.6%，中等：3.9%，严重：1.9%；每个p<0.001)。治疗的总体成功率（总清除或病变减少/下降）为94％。
UNASSIGNED：SJW油按摩似乎对IGM相关的持续性皮肤病变患者非常有效。
