PDF(Pubmed)
Abstract：
We evaluated the effect of diets low in energy density (1 kcal/g) and high in either potatoes (Potato) or pulses (Bean) on blood glucose control in participants with insulin resistance. We hypothesized that the Potato and Bean diets would have equivalent effects. This was an 8-week randomized, parallel design, controlled feeding study comparing Potato and Bean diets (50-55% carbohydrate, 30-35% fat, 15-20% protein). Equivalence was prespecified as the mean change in the blood glucose concentration for Potato that was within ±20% of the Bean diet. Thirty-six participants (age: 18-60 years, body mass index: 25-40 kg/m2) with insulin resistance (homeostatic model assessment of insulin resistance [HOMA-IR] >2) were enrolled. Body weight was measured, and subjects underwent a mixed meal tolerance test at baseline and after 8 weeks. Intent-to-treat (ITT) and completer analyses were conducted. Equivalence between the two diets in the area under the curve for serum glucose was attained within ±10%, but the reduction from baseline was not statistically significant. For the Bean diet, insulin (area under the response curve: -2136.3 ± 955.5 mg/[dL∙min], P = .03) and HOMA-IR (-1.4 ± 0.6, P = .02) were lower compared with baseline. ITT and completer analyses were similar, except that HOMA-IR was also reduced by the Potato diet (-1.3 ± 0.6, P < .05). Compliance with the diets was 87-88%, and body weight was reduced in both diets (Potato: -5.6% ± 0.6%; Bean: -4.1% ± 0.6%, P < .001) with no significant difference between the two diets. Potato and Bean diets low in energy density were equally effective in reducing insulin resistance and promoting weight loss in individuals with impaired blood glucose control. Clinical Trial: The trial was registered with ClinicalTrials.gov Identifier: NCT04203238.
摘要：
我们评估了低能量密度（1kcal/g）和高土豆（马铃薯）或豆类（Bean）饮食对胰岛素抵抗参与者血糖控制的影响。我们假设马铃薯和豆类的饮食将具有相同的效果。这是一个为期8周的随机调查，并行设计,对照饲喂研究，比较马铃薯和豆类的日粮(50-55%碳水化合物，30-35%的脂肪，15-20%蛋白质)。等效性被预先指定为在Bean饮食的±20％范围内的马铃薯的血糖浓度的平均变化。36名参与者（年龄：18-60岁，纳入体重指数：25-40kg/m2）与胰岛素抵抗（胰岛素抵抗的稳态模型评估[HOMA-IR]>2）。测量了体重，受试者在基线和8周后接受混合膳食耐受性测试。进行了意向治疗（ITT）和完成者分析。两种饮食在血清葡萄糖曲线下面积的当量在±10％以内。但相对于基线的减少无统计学意义.对于豆子饮食，胰岛素（反应曲线下面积：-2136.3±955.5mg/[dL·min]，与基线相比，P=.03）和HOMA-IR（-1.4±0.6，P=.02）较低。ITT和完成者分析相似，除了马铃薯日粮还降低了HOMA-IR（-1.3±0.6，P<0.05）。饮食依从性为87-88%，并且两种饮食的体重都降低了（马铃薯：-5.6％±0.6％；豆类：-4.1％±0.6％，P<.001），两种饮食之间没有显着差异。能量密度低的马铃薯和豆类饮食在降低胰岛素抵抗和促进血糖控制受损的个体的体重减轻方面同样有效。临床试验：该试验已在ClinicalTrials.gov标识符：NCT04203238注册。
