METHODS: The cohort study included 12 578 workers from 21 cohorts, with 6626 deaths in total, 858 deaths from lung cancer and 394 from pleural malignant neoplasm (MN). Rate advancement was estimated by fitting a competitive mortality Weibull model to the hazard of death over time since first exposure (TSFE).
RESULTS: Acceleration time (AT) was estimated at different TSFE values. The highest level of cumulative exposure compared with the lowest, for pleural MN AT was 16.9 (95% CI 14.9 to 19.2) and 33.8 (95% CI 29.8 to 38.4) years at TSFE of 20 and 40 years, respectively. For lung cancer, it was 13.3 (95% CI 12.0 to 14.7) and 26.6 (95% CI 23.9 to 29.4) years, respectively. As for total mortality, AT was 3.35 (95% CI 2.98 to 3.71) years at 20 years TSFE, and 6.70 (95% CI 5.95 to 7.41) at 40 years TSFE.
CONCLUSIONS: The current study observed marked rate advancement after asbestos exposure for lung cancer and pleural mesothelioma, as well as for total mortality.
方法:队列研究包括来自21个队列的12578名工人,总共有6626人死亡,858人死于肺癌,394人死于胸膜恶性肿瘤(MN)。通过将竞争性死亡率Weibull模型拟合到自首次暴露(TSFE)以来随时间的死亡风险来估计速率提高。
结果:在不同的TSFE值下估计加速时间(AT)。累积暴露的最高水平与最低水平相比,在20年和40年的TSFE时,胸膜MN的AT为16.9年(95%CI14.9至19.2)和33.8年(95%CI29.8至38.4),分别。对于肺癌,分别为13.3年(95%CI12.0至14.7)和26.6年(95%CI23.9至29.4),分别。至于总死亡率,在20年TSFE时,AT为3.35年(95%CI2.98至3.71),和40年TSFE时的6.70(95%CI5.95至7.41)。
结论:目前的研究观察到石棉暴露后肺癌和胸膜间皮瘤的发生率明显升高,以及总死亡率。