Abstract：
A 69-year-old Japanese man with acute leukemia received post-transplant cyclophosphamide-based haploidentical stem cell transplantation (PTCY-haplo-SCT) but was readmitted with dyspnea and ground-glass-opacities of the lungs. Bronchoscopy showed inflammatory changes with no signs of infection. He received steroids but required intubation as his condition deteriorated. In addition to antithymocyte globulin and cyclophosphamide, we administered ruxolitinib but failed to save him. Autopsy findings revealed fibrotic nonspecific interstitial pneumonia (NSIP) without evidence of organizing pneumonia or infection. Thus, we diagnosed idiopathic pneumonia syndrome (IPS). As far as our knowledge, this is the first case of IPS with NSIP histology after PTCY-haplo-SCT.
摘要：
一名69岁的日本急性白血病患者接受了移植后基于环磷酰胺的单倍体干细胞移植（PTCY-haplo-SCT），但因呼吸困难和肺部玻璃混浊而再次入院。支气管镜检查显示炎症变化，无感染迹象。他接受了类固醇治疗，但由于病情恶化而需要插管。除了抗胸腺细胞球蛋白和环磷酰胺，我们服用了鲁索替尼，但未能挽救他。尸检结果显示纤维化非特异性间质性肺炎（NSIP），没有组织性肺炎或感染的证据。因此，我们诊断为特发性肺炎综合征（IPS）。据我们所知,这是PTCY-haplo-SCT后第一例具有NSIP组织学的IPS。
