Abstract：
IMGT®, the international ImMunoGeneTics information system®, http://www.imgt.org , the global reference in immunogenetics and immunoinformatics, was created in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS) to manage the huge diversity of the antigen receptors, immunoglobulins (IG) or antibodies, and T cell receptors (TR) of the adaptive immune responses. The founding of IMGT® marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT® standardized analysis of the IG, TR, and major histocompatibility (MH) genes and proteins bridges the gap between sequences and three-dimensional (3D) structures, for all jawed vertebrates from fish to humans. This is achieved through the IMGT Scientific chart rules, based on the IMGT-ONTOLOGY axioms, and primarily CLASSIFICATION (IMGT gene and allele nomenclature) and NUMEROTATION (IMGT unique numbering and IMGT Colliers de Perles). IMGT® comprises seven databases (IMGT/LIGM-DB for nucleotide sequences, IMGT/GENE-DB for genes and alleles, etc.), 17 tools (IMGT/V-QUEST, IMGT/JunctionAnalysis, IMGT/HighV-QUEST for NGS, etc.), and more than 20,000 Web resources. In this chapter, the focus is on the tools for amino acid sequences per domain (IMGT/DomainGapAlign and IMGT/Collier-de-Perles), and on the databases for receptors (IMGT/2Dstructure-DB and IMGT/3D-structure-DB) described per receptor, chain, and domain and, for 3D, with contact analysis, paratope, and epitope. The IMGT/mAb-DB is the query interface for monoclonal antibodies (mAb), fusion proteins for immune applications (FPIA), composite proteins for clinical applications (CPCA), and related proteins of interest (RPI) with links to IMGT® 2D and 3D databases and to the World Health Organization (WHO) International Nonproprietary Names (INN) program lists. The chapter includes the human IG allotypes and antibody engineered variants for effector properties used in the description of therapeutical mAb.
摘要：
IMGT®,国际ImMunoGeneTics信息系统®，http://www。imgt.org,免疫遗传学和免疫信息学的全球参考，由Marie-PauleLefranc（蒙彼利埃大学和CNRS）于1989年创建，用于管理抗原受体的巨大多样性，免疫球蛋白（IG）或抗体，和T细胞受体（TR）的适应性免疫反应。IMGT®的成立标志着免疫信息学的出现，出现在免疫遗传学和生物信息学之间的界面。IG的IMGT®标准化分析，TR,和主要组织相容性（MH）基因和蛋白质桥接序列和三维（3D）结构之间的差距，从鱼类到人类的所有下颚脊椎动物。这是通过IMGT科学图表规则实现的，基于IMGT-本体公理，和主要分类（IMGT基因和等位基因命名法）和数字（IMGT独特编号和IMGTColliersdePerles）。IMGT®包含七个数据库（用于核苷酸序列的IMGT/LIGM-DB，用于基因和等位基因的IMGT/GENE-DB，等。),17个工具(IMGT/V-QUEST,IMGT/JunctionAnalysis,用于NGS的IMGT/HighV-QUEST，等。),和超过20,000个Web资源。在这一章中,重点是每个结构域的氨基酸序列工具（IMGT/DomainGapAlign和IMGT/Collier-de-Perles），并在每个受体描述的受体数据库（IMGT/2Dstructure-DB和IMGT/3D-structure-DB）上，链,和域和,对于3D，通过接触分析，paratope,和表位。IMGT/mAb-DB是单克隆抗体（mAb）的查询接口，免疫应用融合蛋白（FPIA），临床应用复合蛋白（CPCA），和相关的感兴趣的蛋白质（RPI），链接到IMGT®2D和3D数据库以及世界卫生组织（WHO）国际非专利名称（INN）计划列表。本章包括用于治疗性mAb描述中的效应物特性的人IG同种异型和抗体工程化变体。
