Abstract：
Intercellular communication is an essential process in all multicellular organisms. During this process, molecules secreted by one cell will bind to a receptor on the cognate cell leading to the subsequent uptake of the receptor-ligand complex. Once inside, the cell then determines the fate of the receptor-ligand complex and any other proteins that were endocytosed together. Approximately 80% of endocytosed material is recycled back to the plasma membrane either directly or indirectly via the Golgi apparatus and the remaining 20% is delivered to the lysosome for degradation. Although most pathways have been identified, we still lack understanding on how specificity in sorting of recycling cargos into different pathways is achieved, and how the cell reaches high accuracy of these processes in the absence of clear sorting signals in the bulk of the client proteins. In this review, we will summarize our current understanding of the mechanism behind recycling cargo sorting and propose a model of differential affinities between cargo and cargo receptors/adaptors with regards to iterative sorting in endosomes.
摘要：
细胞间通讯是所有多细胞生物中必不可少的过程。在这个过程中,一个细胞分泌的分子将与同源细胞上的受体结合，导致随后吸收受体-配体复合物。一旦进去，然后细胞决定受体-配体复合物和任何其他一起被内吞的蛋白质的命运。大约80%的内吞材料直接或间接地通过高尔基体再循环回到质膜,剩余的20%被递送到溶酶体用于降解。虽然已经确定了大多数途径，我们仍然缺乏对如何实现将货物回收到不同途径中的特异性的理解，以及细胞如何在大量客户端蛋白质中没有清晰的分选信号的情况下达到这些过程的高精度。在这次审查中,我们将总结我们目前对回收货物分类背后的机制的理解，并提出一个关于内体迭代分类的货物和货物受体/衔接子之间的差异亲和力模型。
