Abstract：
Microplastics (MPs) and Nanoplastics (NPs) are plastic fragments that spread in the environment and accumulate in the human body, so they have been becoming a worldwide environmental concern because of their potential human health effects. The aim of this systematic review was to investigate the prospective impact of MPs and NPs on the inflammatory process.
Electronic article search was performed on PubMed, Scopus and Web of Science international databases from 1 Jan 2012 to 31 Dec 2021. Screenings of titles, abstracts and full texts were performed according to the Preferred Reporting Item for Systematic Review and Meta-analyses (PRISMA). The methodological quality of the studies was checked by the Toxicological data Reliability Assessment Tool.
Electronic article search identified 125 records, from which 6 in vitro, 11 in vivo and 2 both in vivo and in vitro studies were included. Both in vivo and in vitro studies have showed an increase ofdifferent inflammatory outcomes (Interleukines, Tumor necrosis factor, Chemokines, Interferones, Transcription factors, Growth factors, Oxydoreductase, Proteins and others), thus it seems to confirm the association withthe exposure to microplastics of different types, sizes, exposure times and exposed species.
This systematic review seems to support the relationship between the exposure to MPs and the inflammatory processboth in vivo and in vitro. Greater caution is needed about the role of NPs because ofa very small number of studies. Additional high-quality studies are warranted to confirm these results, especially the research should be focused on NPs being lacking literature.
Electronic article search was performed on PubMed, Scopus and Web of Science international databases from 1 Jan 2012 to 31 Dec 2021. Screenings of titles, abstracts and full texts were performed according to the Preferred Reporting Item for Systematic Review and Meta-analyses (PRISMA). The methodological quality of the studies was checked by the Toxicological data Reliability Assessment Tool.
Electronic article search identified 125 records, from which 6 in vitro, 11 in vivo and 2 both in vivo and in vitro studies were included. Both in vivo and in vitro studies have showed an increase ofdifferent inflammatory outcomes (Interleukines, Tumor necrosis factor, Chemokines, Interferones, Transcription factors, Growth factors, Oxydoreductase, Proteins and others), thus it seems to confirm the association withthe exposure to microplastics of different types, sizes, exposure times and exposed species.
This systematic review seems to support the relationship between the exposure to MPs and the inflammatory processboth in vivo and in vitro. Greater caution is needed about the role of NPs because ofa very small number of studies. Additional high-quality studies are warranted to confirm these results, especially the research should be focused on NPs being lacking literature.
摘要：
微塑料（MPs）和纳米塑料（NPs）是在环境中扩散并在人体内积聚的塑料碎片，因此，由于它们对人类健康的潜在影响，它们已成为全世界关注的环境问题。本系统评价的目的是研究MPs和NPs对炎症过程的预期影响。
在PubMed上进行电子文章搜索，2012年1月1日至2021年12月31日的Scopus和WebofScience国际数据库。标题的放映，摘要和全文根据系统评价和荟萃分析（PRISMA）的首选报告项目进行。通过毒理学数据可靠性评估工具检查了研究的方法学质量。
电子文章搜索确定了125条记录，其中6个在体外，包括11个体内和2个体内和体外研究。体内和体外研究都显示了不同炎症结果的增加（白细胞介素，肿瘤坏死因子,趋化因子,干扰素,转录因子,生长因子,氧还原酶,蛋白质及其他），因此，它似乎证实了与不同类型的微塑料接触的关联，尺寸,暴露时间和暴露物种。
本系统综述似乎支持体内和体外暴露于MPs与炎症过程之间的关系。由于研究数量很少，因此需要对NPs的作用更加谨慎。需要额外的高质量研究来证实这些结果，特别是研究应集中在缺乏文献的NP上。
在PubMed上进行电子文章搜索，2012年1月1日至2021年12月31日的Scopus和WebofScience国际数据库。标题的放映，摘要和全文根据系统评价和荟萃分析（PRISMA）的首选报告项目进行。通过毒理学数据可靠性评估工具检查了研究的方法学质量。
电子文章搜索确定了125条记录，其中6个在体外，包括11个体内和2个体内和体外研究。体内和体外研究都显示了不同炎症结果的增加（白细胞介素，肿瘤坏死因子,趋化因子,干扰素,转录因子,生长因子,氧还原酶,蛋白质及其他），因此，它似乎证实了与不同类型的微塑料接触的关联，尺寸,暴露时间和暴露物种。
本系统综述似乎支持体内和体外暴露于MPs与炎症过程之间的关系。由于研究数量很少，因此需要对NPs的作用更加谨慎。需要额外的高质量研究来证实这些结果，特别是研究应集中在缺乏文献的NP上。
