Abstract：
Post-vaccination safety is a major public health concern. The genetic predisposition on immune response has not been clearly identified. Clarifying whether individual genetic predisposition plays a role on adverse events (AEs) is critical for the prevention of AEs.
From July 2019 to June 2020, we performed a case-control study among children aged 3-24 months in seven Chinese provinces. Each child received a combination vaccination against diphtheria, tetanus, acellular pertussis, and Haemophilus influenzae type b (DTaP-Hib). Through daily telephone follow-up, we collected AEs within seven days. Oral swab samples were collected to investigate the effects of single nucleotide polymorphisms (SNPs) on the risk of AEs.
304 participants were included in the study. In univariate analysis, we discovered three protective SNPs (rs452204, OR = 0.67, P = 0.0352; rs9282763 and rs839, OR = 0.64, P = 0.0256) and one risk SNP (rs9610, OR = 2.20, P = 0.0397). In multivariate analysis, the effects of rs452204 and rs839 were found to be stable. The interaction between rs452204 and rs9610 was observed (OR = 7.25, 95% CI: 1.44-36.58, P = 0.0165).
Genetic predisposition was associated with the risk of AEs after DTaP-Hib vaccination, emphasizing the potential application in the prevention of AEs.
From July 2019 to June 2020, we performed a case-control study among children aged 3-24 months in seven Chinese provinces. Each child received a combination vaccination against diphtheria, tetanus, acellular pertussis, and Haemophilus influenzae type b (DTaP-Hib). Through daily telephone follow-up, we collected AEs within seven days. Oral swab samples were collected to investigate the effects of single nucleotide polymorphisms (SNPs) on the risk of AEs.
304 participants were included in the study. In univariate analysis, we discovered three protective SNPs (rs452204, OR = 0.67, P = 0.0352; rs9282763 and rs839, OR = 0.64, P = 0.0256) and one risk SNP (rs9610, OR = 2.20, P = 0.0397). In multivariate analysis, the effects of rs452204 and rs839 were found to be stable. The interaction between rs452204 and rs9610 was observed (OR = 7.25, 95% CI: 1.44-36.58, P = 0.0165).
Genetic predisposition was associated with the risk of AEs after DTaP-Hib vaccination, emphasizing the potential application in the prevention of AEs.
摘要：
疫苗接种后的安全性是主要的公共卫生问题。尚未明确确定免疫反应的遗传易感性。阐明个体遗传易感性是否在不良事件（AE）中起作用对于预防AE至关重要。
从2019年7月到2020年6月，我们在中国七个省份的3-24个月儿童中进行了病例对照研究。每个孩子都接受了白喉联合疫苗接种，破伤风,无细胞百日咳，和b型流感嗜血杆菌（DTaP-Hib）。通过每日电话随访,我们在7天内收集了AE。收集口腔拭子样品以研究单核苷酸多态性（SNP）对AE风险的影响。
304名参与者被纳入研究。在单变量分析中，我们发现了三个保护性SNP（rs452204，OR=0.67，P=0.0352；rs9282763和rs839，OR=0.64，P=0.0256）和一个风险SNP（rs9610，OR=2.20，P=0.0397）。在多变量分析中，发现rs452204和rs839的作用是稳定的。rs452204和rs9610之间存在相互作用(OR=7.25,95%CI:1.44-36.58,P=0.0165)。
遗传易感性与DTaP-Hib疫苗接种后的AE风险相关，强调在预防AE中的潜在应用。
从2019年7月到2020年6月，我们在中国七个省份的3-24个月儿童中进行了病例对照研究。每个孩子都接受了白喉联合疫苗接种，破伤风,无细胞百日咳，和b型流感嗜血杆菌（DTaP-Hib）。通过每日电话随访,我们在7天内收集了AE。收集口腔拭子样品以研究单核苷酸多态性（SNP）对AE风险的影响。
304名参与者被纳入研究。在单变量分析中，我们发现了三个保护性SNP（rs452204，OR=0.67，P=0.0352；rs9282763和rs839，OR=0.64，P=0.0256）和一个风险SNP（rs9610，OR=2.20，P=0.0397）。在多变量分析中，发现rs452204和rs839的作用是稳定的。rs452204和rs9610之间存在相互作用(OR=7.25,95%CI:1.44-36.58,P=0.0165)。
遗传易感性与DTaP-Hib疫苗接种后的AE风险相关，强调在预防AE中的潜在应用。
