PDF(Pubmed)
Abstract：
Cerebrovascular dysfunction has been suggested as a physiomarker of Alzheimer\'s disease (AD)-associated neuronal degeneration, but the underlying mechanisms are still debated. Herein cerebral vasomotor reactivity (VMR, breath-hold index: BHI), metabolic activity (lobar SUVs, FDG PET MRI), amyloid load (Centiloid score, Flutemetamol PET MRI), hemispheric cortical thickness, white matter lesion load and cerebral blood flow (ASL) were studied in 43 consecutive subjects (mean age: 64 years, female 13), diagnosed with subjective cognitive impairment (SCI, n = 10), amnestic mild cognitive impairment (aMCI, n = 15), and probable Alzheimer\'s dementia (AD, n = 18). BHI was significantly reduced in AD and aMCI patients compared to SCI subjects. A highly significant inverse correlation was found between BHI and the centiloid score (r = -0.648, p < 0.001). There was moderate positive correlation between BHI and frontal, temporal and parietal FDG SUV and ASL values, and a borderline negative correlation with age and white matter lesion volume. The link between amyloid burden and VMR was independent and strong in linear regression models where all these parameters were included (β from -0.580 to -0.476, p < 0.001). In conclusion, our study confirms the negative association of cerebral amyloid accumulation and vasomotor reactivity in Alzheimer\'s disease with the most direct data to date in humans.
摘要：
脑血管功能障碍已被认为是阿尔茨海默病（AD）相关神经元变性的生理标志，但是潜在的机制仍在争论中。在此脑血管舒缩反应性(VMR，屏气指数：BHI），代谢活动(叶SUV，FDGPETMRI），淀粉样蛋白负荷（Centiloid评分，FlutemetamolPETMRI），半球皮质厚度，在43名连续受试者中研究了白质病变负荷和脑血流量（ASL）（平均年龄：64岁，female13),诊断为主观认知障碍（SCI，n=10），遗忘型轻度认知障碍（aMCI，n=15），和可能的老年痴呆症(AD，n=18)。与SCI受试者相比,AD和aMCI患者中的BHI显著降低。在BHI和centloid评分之间发现了高度显着的负相关（r=-0.648，p<0.001）。BHI与额叶呈中度正相关，颞叶和顶叶FDGSUV和ASL值，与年龄和白质病变体积呈临界负相关。在包括所有这些参数的线性回归模型中，淀粉样蛋白负荷与VMR之间的联系是独立且牢固的（β从-0.580到-0.476，p<0.001）。总之,我们的研究证实了阿尔茨海默病中脑淀粉样蛋白积累和血管舒缩反应性与人类迄今最直接的数据呈负相关.
