Abstract：
OBJECTIVE: Handgrip strength (HGS) is an indicator of general muscular strength and in cancer patients acts as a relevant marker associated with mortality and health. This study aimed to evaluate the association between peripheral muscle function and health-related quality of life (HRQoL) in breast cancer (BC) survivors.
METHODS: Systematic review registered on PROSPERO under number: CRD 42021225206. The searches were carried out on MEDLINE via Pubmed, PEDro, Cochrane Library, Embase, CINAHL via EBSCO and Science Direct databases. Observational studies evaluating the association between handgrip strength (HGS) and HRQoL in adult female BC survivors were included. No linguistic or time restrictions were applied. Two reviewers reviewed full texts for inclusion and performed data extraction and risk of bias using the Newcastle and Ottawa scale (NOS).
RESULTS: Five articles were included and involved 587 patients, mean age of 47 to 59 years. The percentage of decreased HGS ranged from 38.3% to 60.3%. HGS was associated with different quality of life measures. From meta-analysis including 220 patients, the correlation coefficient between HGS and HRQoL was 0.26 (95% CI: 0.07-0.35).
CONCLUSIONS: Breast cancer survivors face decline of HGS. In this population HGS was correlated with HRQoL. However, more evidence are necessary.
METHODS: Systematic review registered on PROSPERO under number: CRD 42021225206. The searches were carried out on MEDLINE via Pubmed, PEDro, Cochrane Library, Embase, CINAHL via EBSCO and Science Direct databases. Observational studies evaluating the association between handgrip strength (HGS) and HRQoL in adult female BC survivors were included. No linguistic or time restrictions were applied. Two reviewers reviewed full texts for inclusion and performed data extraction and risk of bias using the Newcastle and Ottawa scale (NOS).
RESULTS: Five articles were included and involved 587 patients, mean age of 47 to 59 years. The percentage of decreased HGS ranged from 38.3% to 60.3%. HGS was associated with different quality of life measures. From meta-analysis including 220 patients, the correlation coefficient between HGS and HRQoL was 0.26 (95% CI: 0.07-0.35).
CONCLUSIONS: Breast cancer survivors face decline of HGS. In this population HGS was correlated with HRQoL. However, more evidence are necessary.
摘要：
目的：握力（HGS）是一般肌肉力量的指标，在癌症患者中作为与死亡率和健康状况相关的指标。这项研究旨在评估乳腺癌（BC）幸存者的外周肌肉功能与健康相关生活质量（HRQoL）之间的关系。
方法：在PROSPERO上注册的系统审查，编号：CRD42021225206。搜索是通过Pubmed在MEDLINE上进行的，PEDro,科克伦图书馆,Embase,CINAHL通过EBSCO和ScienceDirect数据库。纳入了评估成年女性BC幸存者中手握力（HGS）与HRQoL之间关系的观察性研究。没有语言或时间限制。两名审稿人回顾了全文，并使用纽卡斯尔和渥太华量表（NOS）进行了数据提取和偏倚风险。
结果：共纳入5篇，涉及587例患者，平均年龄47至59岁。HGS降低的百分比范围为38.3%至60.3%。HGS与不同的生活质量指标相关。从包括220名患者的荟萃分析来看，HGS与HRQoL之间的相关系数为0.26（95％CI：0.07-0.35）。
结论：乳腺癌幸存者面临HGS下降。在该人群中，HGS与HRQoL相关。然而,更多的证据是必要的。
方法：在PROSPERO上注册的系统审查，编号：CRD42021225206。
结果：共纳入5篇，涉及587例患者，
结论：乳腺癌幸存者面临HGS下降。
