Abstract：
Since the introduction of Haemophilus influenzae (Hi) serotype b (Hib) vaccination, reports of increasing incidence rates of non-Hib serotypes have emerged. A systematic review was performed to investigate whether the Hi serotype f (Hif) incidence rate has increased globally and to describe its associated disease burden. In the post-Hib vaccine era, evidence shows that the incidence rate of Hif infection is increasing worldwide. In total 94 studies including 2 701 patients reported Hif infections. The estimated pooled incidence rate of Hif infection was 0.15/100 000 population per year (range: 0.05-0.40/100 000), with a median case fatality ratio of 14.3 %. Invasive infections most frequently presented as pneumonia (45 %), septicaemia (34 %) and meningitis (20 %). Of 191 Hif isolates, 87 % were ampicillin-susceptible. Multi-locus sequence typing revealed that Hif were relatively clonal, with the majority belonging to clonal complex 124. Hif causes invasive infections of significant variance in both severity and presentation. Globally, the Hif population shows little genetic variability and currently appears to possess low resistance to antimicrobials.
摘要：
自从引入流感嗜血杆菌（Hi）血清型b（Hib）疫苗以来，非Hib血清型发病率增加的报道已经出现.进行了系统评价，以调查Hi血清型f（Hif）发病率是否在全球范围内增加，并描述其相关的疾病负担。在后Hib疫苗时代,证据表明，全球HIF感染的发病率正在增加。在总共94项研究中，包括2701名患者报告了Hif感染。Hif感染的估计合并发病率为每年0.15/100000人（范围：0.05-0.40/100000），病例死亡率中位数为14.3%。侵袭性感染最常表现为肺炎（45%），败血症（34%）和脑膜炎（20%）。在191个希夫分离株中，87%是氨苄青霉素敏感型。多位点序列分型显示Hif是相对克隆的，大部分属于克隆复合体124。Hif导致严重程度和表现均存在显著差异的侵入性感染。全球范围内,Hif种群几乎没有遗传变异，目前似乎对抗菌药物的耐药性较低。
