关键词: COVID-19 vaccination anosmia hyposmia olfactory bulb olfactory dysfunction smell and taste disorders tinnitus vaccine adverse reaction COVID-19 vaccination anosmia hyposmia olfactory bulb olfactory dysfunction smell and taste disorders tinnitus vaccine adverse reaction

来  源:   DOI:10.1515/tnsci-2022-0250   PDF(Pubmed)

Abstract:
UNASSIGNED: Rare and mild adverse effects on cranial nerves have been reported after vaccination. Here, we report a singular case of smell and taste disorder associated with tinnitus that occurred after Oxford-AstraZeneca vaccination together with a review of the available literature.
UNASSIGNED: A 76-year-old patient experienced smell disorder, ear fullness and tinnitus 2 days after the first dose of Oxford-AstraZeneca vaccine. The patient then underwent a complete audiological and Ear, Nose and Throat evaluation, nasal endoscopy, Sniffin\'Sticks battery, audiometric test battery, and cerebral magnetic resonance imaging (MRI). The exams revealed hyposmia and bilateral reduction of the volume of the olfactory bulbs (OB). At the follow-up, tinnitus was completely resolved while olfactory dysfunction only partially reduced.
UNASSIGNED: A PubMed search was conducted on olfactory and gustatory dysfunctions after COVID-19 vaccination resulting in four case reports with a total of 10 patients. The main symptoms were hyposmia, parosmia, and dysgeusia developed after 1-9 days from vaccination with complete resolution occurring within 1 month. Notably, none of the considered articles reported reduction of OB volumes at cerebral MRI.
UNASSIGNED: So far, no definitive cause-effect relationship has been established between anti-COVID19 vaccination and otolaryngologic adverse reactions. The persistence of hyposmia in our patient could possibly be explained by the reduction in OB volume, even though also the advanced age of the patient needs to be taken into account. This is a first indication of a cause-effect relation between hyposmia and Covid19 vaccination, even though a more robust study is needed to confirm the autoimmunological mechanisms responsible for these rare adverse reactions. However, it is worth highlighting that benefits of the anti-COVID-19 vaccination clearly outweigh the risk of rare adverse events.
摘要:
未经证实:据报道,接种疫苗后对颅神经有罕见和轻微的不良反应。这里,我们报告了1例牛津-阿斯利康疫苗接种后发生的与耳鸣相关的嗅觉和味觉障碍病例,并对现有文献进行了综述.
未经证实:一名76岁患者出现嗅觉障碍,第一剂牛津-阿斯利康疫苗接种后2天耳胀和耳鸣。然后病人接受了完整的听力学和耳朵,鼻子和喉咙评估,鼻内窥镜检查,Sniffin\'粘住电池,听力测试电池,和脑磁共振成像(MRI)。检查显示嗅觉减退和双侧嗅球(OB)体积减少。在后续行动中,耳鸣完全解决,而嗅觉功能障碍仅部分减少。
UNASSIGNED:PubMed对COVID-19疫苗接种后的嗅觉和味觉功能障碍进行了检索,得出4例病例报告,共10例患者。主要症状是食欲不振,parosmia,和味觉障碍在接种疫苗1-9天后出现,并在1个月内完全缓解。值得注意的是,考虑的文章均未报道脑MRI时OB体积减少。
未经批准:到目前为止,在抗COVID19疫苗接种和耳鼻喉科不良反应之间没有明确的因果关系.我们的患者持续的食欲不振可能可以通过OB体积减少来解释,尽管还需要考虑患者的高龄。这首次表明了低代血症和Covid19疫苗接种之间的因果关系,即使需要更有力的研究来确认导致这些罕见不良反应的自身免疫机制.然而,值得强调的是,抗COVID-19疫苗接种的益处明显大于罕见不良事件的风险.
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