Abstract：
The \"thrifty genotype\" hypothesis has thus far described the relationship between specific genes and the population\'s resilience to food scarcity circumstances, but its link to the widespread prevalence of genetic diseases and metabolic syndrome has not been adequately mapped. The purpose of the study was to discover genes responsible for thrifty metabolism. A systematic search with keywords was performed for relevant titles. This study used the article\'s database published by Pubmed, Proquest, and EBSCO from January, 2009 to September, 2022. Out of 418 papers screened for eligibility, the final evaluation determined that five studies should be included in the analysis. Results indicated that PPARGC1A Gly482Ser led to high BMI in the Tongans population but was unrelated to the onset of type 2 diabetes mellitus, but this was not the case in the Maori population. Significantly differing frequencies of PPAR C1431T and Pro12Ala gene polymorphisms were observed in the Iranian population. GWAS identification of additional genes in Asian and European populations did not produce consistent findings. As a summary, PPARGC1A Gly482Ser addresses as the gene responsible for thrifty metabolism in the Pacific population although some studies show inconsistent results.
摘要：
到目前为止，“节俭基因型”假说描述了特定基因与人群对食物短缺环境的抵抗力之间的关系，但其与广泛流行的遗传疾病和代谢综合征的联系尚未得到充分的定位.这项研究的目的是发现负责节俭代谢的基因。对相关标题进行了带有关键字的系统搜索。本研究使用了Pubmed发布的文章数据库，Proquest,和EBSCO从一月开始，2009年9月,2022年。在418篇筛选合格论文中，最终评估确定5项研究应纳入分析.结果表明，PPARGC1AGly482Ser导致了汤加人的高BMI，但与2型糖尿病的发病无关。但毛利人的情况并非如此。在伊朗人群中观察到PPARC1431T和Pro12Ala基因多态性的频率显着不同。亚洲和欧洲人群中其他基因的GWAS鉴定没有产生一致的发现。作为总结，PPARGC1AGly482Ser认为是太平洋人群节俭代谢的基因，尽管一些研究显示结果不一致。
