Abstract：
Aspirin-exacerbated respiratory disease (AERD) is characterized by abnormal arachidonic acid metabolism leading to chronic rhinosinusitis with nasal polyposis (CRSwNP), asthma, and upper and/or lower respiratory symptoms after ingestion of cyclooxygenase-1 inhibiting nonsteroidal antiinflammatory drugs. Diagnosis is clinical and may involve an aspirin challenge. Inflammatory biomarkers may be useful for diagnosis and treatment monitoring. Conventional medical management for asthma and CRSwNP is often inadequate. Endoscopic sinus surgery followed by continued medical management with or without aspirin desensitization frequently improves symptoms and objective disease measures. Biological agents targeting eosinophilic inflammation are promising alternatives to conventional management.
摘要：
阿司匹林加剧的呼吸系统疾病（AERD）的特征是花生四烯酸代谢异常，导致慢性鼻-鼻窦炎伴鼻息肉病（CRSwNP）。哮喘,摄入环氧合酶-1抑制非甾体抗炎药后的上和/或下呼吸道症状。诊断是临床的，可能涉及阿司匹林攻击。炎性生物标志物可用于诊断和治疗监测。哮喘和CRSwNP的常规医学管理通常是不充分的。内窥镜鼻窦手术后继续进行有或没有阿司匹林脱敏的医疗管理通常会改善症状和客观疾病措施。针对嗜酸性粒细胞性炎症的生物制剂是常规治疗的有希望的替代方案。
