Abstract：
BACKGROUND: A broad spectrum of skin diseases, including hair and nails, can be directly or indirectly triggered by COVID-19. It is aimed to examine the type and frequency of hair and nail disorders after COVID-19 infection.
METHODS: This is a multicenter study conducted on consecutive 2171 post-COVID-19 patients. Patients who developed hair and nail disorders and did not develop hair and nail disorders were recruited as subject and control groups. The type and frequency of hair and nail disorders were examined.
RESULTS: The rate of the previous admission in hospital due to COVID-19 was statistically significantly more common in patients who developed hair loss after getting infected with COVID-19 (P < 0.001). Telogen effluvium (85%) was the most common hair loss type followed by worsening of androgenetic alopecia (7%) after COVID-19 infection. The mean stress scores during and after getting infected with COVID-19 were 6.88 ± 2.77 and 3.64 ± 3.04, respectively, in the hair loss group and were 5.77 ± 3.18 and 2.81 ± 2.84, respectively, in the control group (P < 0.001, P < 0.001). The frequency of recurrent COVID-19 was statistically significantly higher in men with severe androgenetic alopecia (Grades 4-7 HNS) (P = 0.012; Odds ratio: 2.931 [1.222-7.027]). The most common nail disorders were leukonychia, onycholysis, Beau\'s lines, onychomadesis, and onychoschisis, respectively. The symptoms of COVID-19 were statistically significantly more common in patients having nail disorders after getting infected with COVID-19 when compared to the control group (P < 0.05).
CONCLUSIONS: The development of both nail and hair disorders after COVID-19 seems to be related to a history of severe COVID-19.
METHODS: This is a multicenter study conducted on consecutive 2171 post-COVID-19 patients. Patients who developed hair and nail disorders and did not develop hair and nail disorders were recruited as subject and control groups. The type and frequency of hair and nail disorders were examined.
RESULTS: The rate of the previous admission in hospital due to COVID-19 was statistically significantly more common in patients who developed hair loss after getting infected with COVID-19 (P < 0.001). Telogen effluvium (85%) was the most common hair loss type followed by worsening of androgenetic alopecia (7%) after COVID-19 infection. The mean stress scores during and after getting infected with COVID-19 were 6.88 ± 2.77 and 3.64 ± 3.04, respectively, in the hair loss group and were 5.77 ± 3.18 and 2.81 ± 2.84, respectively, in the control group (P < 0.001, P < 0.001). The frequency of recurrent COVID-19 was statistically significantly higher in men with severe androgenetic alopecia (Grades 4-7 HNS) (P = 0.012; Odds ratio: 2.931 [1.222-7.027]). The most common nail disorders were leukonychia, onycholysis, Beau\'s lines, onychomadesis, and onychoschisis, respectively. The symptoms of COVID-19 were statistically significantly more common in patients having nail disorders after getting infected with COVID-19 when compared to the control group (P < 0.05).
CONCLUSIONS: The development of both nail and hair disorders after COVID-19 seems to be related to a history of severe COVID-19.
摘要：
背景：广泛的皮肤病，包括头发和指甲,可由COVID-19直接或间接触发。目的是检查COVID-19感染后头发和指甲疾病的类型和频率。
方法：这是一项对连续2171名COVID-19患者进行的多中心研究。将出现毛发和指甲病症且未出现毛发和指甲病症的患者招募为受试者组和对照组。检查了头发和指甲疾病的类型和频率。
结果：在COVID-19感染后出现脱发的患者中，以前因COVID-19入院的发生率在统计学上更常见（P<0.001）。在COVID-19感染后，静止原脱发（85％）是最常见的脱发类型，其次是雄激素性脱发恶化（7％）。COVID-19感染期间和感染后的平均应激评分分别为6.88±2.77和3.64±3.04，脱发组分别为5.77±3.18和2.81±2.84,对照组(P<0.001,P<0.001)。在患有严重雄激素性脱发（4-7级HNS）的男性中，COVID-19的复发频率显着升高（P=0.012；几率：2.931[1.222-7.027]）。最常见的指甲疾病是白甲，甲状腺溶解症,Beau\的台词,甲癣,和onychoschisis，分别。与对照组相比，COVID-19感染后指甲疾病患者的症状更常见（P<0.05）。
结论：COVID-19后指甲和头发疾病的发展似乎与严重的COVID-19病史有关。
方法：这是一项对连续2171名COVID-19患者进行的多中心研究。将出现毛发和指甲病症且未出现毛发和指甲病症的患者招募为受试者组和对照组。检查了头发和指甲疾病的类型和频率。
结果：在COVID-19感染后出现脱发的患者中，以前因COVID-19入院的发生率在统计学上更常见（P<0.001）。在COVID-19感染后，静止原脱发（85％）是最常见的脱发类型，其次是雄激素性脱发恶化（7％）。COVID-19感染期间和感染后的平均应激评分分别为6.88±2.77和3.64±3.04，脱发组分别为5.77±3.18和2.81±2.84,对照组(P<0.001,P<0.001)。在患有严重雄激素性脱发（4-7级HNS）的男性中，COVID-19的复发频率显着升高（P=0.012；几率：2.931[1.222-7.027]）。最常见的指甲疾病是白甲，甲状腺溶解症,Beau\的台词,甲癣,和onychoschisis，分别。与对照组相比，COVID-19感染后指甲疾病患者的症状更常见（P<0.05）。
结论：COVID-19后指甲和头发疾病的发展似乎与严重的COVID-19病史有关。
