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Abstract：
Stroke represents a major cause of mortality and long-term disability among adult populations, leaving a devastating socioeconomic impact globally. Clinical manifestation of stroke is characterized by great diversity, ranging from minor disability to considerable neurological impairment interfering with activities of daily living and even death. Prognostic ambiguity has stimulated the interest for implementing stroke recovery biomarkers, including those provided by structural neuroimaging techniques, i.e., diffusion tensor imaging (DTI) and tractography for the study of white matter (WM) integrity. Considering the necessity of prompt and accurate prognosis in stroke survivors along with the potential capacity of DTI as a relevant imaging biomarker, the purpose of our study was to review the pertinent literature published within the last decade regarding DTI as a prognostic tool for recovery in acute and hyperacute stroke. We conducted a thorough literature search in two databases (MEDLINE and Science Direct) in order to trace all relevant studies published between 1 January 2012 and 16 March 2022 using predefined terms as key words. Only full-text human studies published in the English language were included. Forty-four studies were identified and are included in this review. We present main findings and by describing several methodological issues, we highlight shortcomings and gaps in the current literature so that research priorities for future research can be outlined. Our review suggests that DTI can track longitudinal changes and identify prognostic correlates in acute and hyperacute stroke patients.
摘要：
卒中是成年人群死亡和长期残疾的主要原因。在全球范围内留下毁灭性的社会经济影响。脑卒中的临床表现具有很大的多样性,从轻微的残疾到严重的神经系统损害，干扰日常生活活动，甚至死亡。预后的模糊性激发了人们对实施卒中恢复生物标志物的兴趣，包括那些由结构神经成像技术提供的，即，弥散张量成像（DTI）和纤维束成像研究白质（WM）的完整性。考虑到卒中幸存者及时准确预后的必要性，以及DTI作为相关成像生物标志物的潜在能力，我们的研究目的是回顾过去10年发表的有关DTI作为急性和超急性卒中恢复的预后工具的相关文献.我们在两个数据库（MEDLINE和ScienceDirect）中进行了全面的文献检索，以追踪2012年1月1日至2022年3月16日期间发表的所有相关研究，使用预定义的术语作为关键词。仅包括以英语发表的全文人类研究。确定了44项研究，并纳入本综述。我们提出了主要的发现，并通过描述几个方法论问题，我们强调了当前文献中的不足和差距，以便可以概述未来研究的研究重点。我们的综述表明，DTI可以追踪急性和超急性卒中患者的纵向变化并确定预后相关因素。
