PDF(Pubmed)
Abstract：
Infections with the Gram-positive bacterial pathogen Staphylococcus aureus remain a major challenge for the healthcare system and demand new treatment options. The increasing antibiotic resistance of S. aureus poses additional challenges, consequently inflicting a huge strain in the society due to enormous healthcare costs. S. aureus expresses multiple molecules, including bacterial lipoproteins (Lpps), which play a role not only in immune response but also in disease pathogenesis. S. aureus Lpps, the predominant ligands of TLR2, are important for bacterial survival as they maintain the metabolic activity of the bacteria. Moreover, Lpps possess many diverse properties that are of vital importance for the bacteria. They also contribute to host cell invasion but so far their role in different staphylococcal infections has not been fully defined. In this review, we summarize the current knowledge about S. aureus Lpps and their distinct roles in various infectious disease animal models, such as septic arthritis, sepsis, and skin and soft tissue infections. The molecular and cellular response of the host to S. aureus Lpp exposure is also a primary focus.
摘要：
革兰氏阳性细菌病原体金黄色葡萄球菌的感染仍然是医疗保健系统的主要挑战，需要新的治疗选择。金黄色葡萄球菌不断增加的抗生素耐药性带来了额外的挑战，因此，由于巨大的医疗费用，给社会带来了巨大的压力。金黄色葡萄球菌表达多种分子，包括细菌脂蛋白（Lpps），它不仅在免疫反应中起作用，而且在疾病的发病机理中起作用。金黄色葡萄球菌Lpps，TLR2的主要配体对于细菌存活是重要的,因为它们维持细菌的代谢活性。此外，Lpps具有许多不同的特性，这些特性对细菌至关重要。它们也有助于宿主细胞的侵袭，但到目前为止，它们在不同葡萄球菌感染中的作用尚未完全确定。在这次审查中,我们总结了目前有关金黄色葡萄球菌Lpps的知识及其在各种传染病动物模型中的不同作用，比如化脓性关节炎，脓毒症,皮肤和软组织感染.宿主对金黄色葡萄球菌Lpp暴露的分子和细胞反应也是主要焦点。
