Abstract：
To determine the estimated pertussis incidence in adults and the need for a booster dose by detecting pertussis and diphtheria antibody levels in adults in Shaanxi province, China. Blood samples were collected from healthy individuals aged 18-59 years in Shaanxi province in 2017. Serum immunoglobulin G (IgG) antibodies against pertussis toxin (PT) and diphtheria toxin (DT) were determined using enzyme-linked immunosorbent assay. The data on reported pertussis cases in Shaanxi province were collected from the China Information System for Disease Control and Prevention and compared with the results of this study. A total of 4307 subjects were enrolled. The mean concentration of anti-PT IgG was 19.6 IU/mL (95% CI = 18.9-20.3), and the positive rate (≥40 IU/mL) was 11.0% (474/4307), of which recent infections (≥100 IU/mL) accounted for 1.2% (53/4307). Only one adult case of pertussis was reported in 2017, which is much lower than the results of this study. The mean concentration of anti-DT IgG was 0.04 IU/mL (95% CI = 0.04-0.05), and the positive rate (≥0.01 IU/mL) was 82.3% (3543/4307). The mean concentration of anti-DT IgG decreased from 0.07 IU/mL in the 18-29 year-old group to 0.03 IU/mL in the 50-59 year-old-group, and the positivity rate decreased from 86.7% to 78.7%. Our study suggests that pertussis is not uncommon among adults. The existing surveillance system might have underestimated the true incidence of pertussis. The diphtheria antibody levels decreased with age. Booster vaccination against pertussis should be considered for adolescents and young adults.
摘要：
通过检测陕西省成人百日咳和白喉抗体水平，确定成人百日咳的估计发病率和是否需要加强剂量。中国。2017年采集陕西省18-59岁健康人群的血液样本。血清免疫球蛋白G（IgG）抗体的百日咳毒素（PT）和白喉毒素（DT）使用酶联免疫吸附试验测定。从中国疾病预防控制信息系统收集陕西省百日咳报告病例数据，并与本研究结果进行比较。共纳入4307名受试者。抗PTIgG的平均浓度为19.6IU/mL（95％CI=18.9-20.3），阳性率(≥40IU/mL)为11.0%(474/4307)，其中近期感染（≥100IU/mL）占1.2％（53/4307）。2017年仅报告了一例成人百日咳病例，远低于本研究的结果。抗DTIgG的平均浓度为0.04IU/mL（95％CI=0.04-0.05），阳性率(≥0.01IU/mL)为82.3%(3543/4307)。抗DTIgG的平均浓度从18-29岁组的0.07IU/mL下降到50-59岁组的0.03IU/mL，阳性率从86.7%下降到78.7%。我们的研究表明，百日咳在成年人中并不少见。现有的监测系统可能低估了百日咳的真实发病率。白喉抗体水平随年龄增长而降低。青少年和年轻人应考虑接种百日咳疫苗。
