PDF(Pubmed)
Abstract：
Lutein and zeaxanthin (L + Z) are carotenoids that accumulate in neural tissue and potentially confer benefits to cognition. Whereas cross-sectional studies have revealed positive associations between macular carotenoids (MC) and cognition, no studies have investigated whether L + Z supplementation impacts MC and cognition in childhood. Accordingly, the Integrated Childhood Ocular Nutrition Study aims to investigate the impact of L + Z supplementation over 9-months on academic abilities, attentional control, memory, and MC among preadolescent children. Children 8-10 years (N = 288) will enroll in a 9-month double-blind, placebo-controlled, randomized trial. The study is registered and approved as a clinical trial on the U.S. National Library of Medicine http://ClinicalTrials.gov registry (NCT05177679). Participants will be randomized into an active (10 mg lutein+2 mg zeaxanthin) or waitlist placebo-controlled group. Primary outcomes include hippocampal-dependent memory, attentional inhibition, and academic achievement using a spatial reconstruction task, an Eriksen flanker task, and the Kaufman Test of Academic and Educational Achievement 3rd edition, respectively. Secondary outcomes include event-related brain potentials of attentional resource allocation and information processing speed (i.e., P3/P300 amplitude and latency) recorded during the flanker task. Macular pigment optical density (MPOD) will be assessed using heterochromatic flicker photometry. Cognitive assessments will be completed prior to and after completion of the supplementation period. MPOD will be quantified prior to, at the mid-point of (4-5 months), and after (9 months) the supplementation period. It is hypothesized that L + Z supplementation will improve cognition and academic achievement. Further, benefits for cognition and achievement are anticipated to be mediated by increases in MC among treatment group participants.
摘要：
叶黄素和玉米黄质(L+Z)是在神经组织中积累并潜在地赋予认知益处的类胡萝卜素。而横断面研究揭示了黄斑类胡萝卜素（MC）和认知之间的正相关，没有研究调查补充L+Z是否影响儿童的MC和认知。因此，儿童眼部营养综合研究旨在调查9个月以上补充L+Z对学术能力的影响，注意控制，记忆,和MC在青春期前儿童中。8-10岁的儿童（N=288）将参加9个月的双盲，安慰剂对照,随机试验。该研究已在美国国家医学图书馆http://ClinicalTrials.gov注册表（NCT05177679）上注册并批准为临床试验。参与者将被随机分为一个活性（10毫克叶黄素+2毫克玉米黄质）或等待安慰剂对照组。主要结果包括海马依赖性记忆，注意力抑制，和使用空间重建任务的学术成就，Eriksen侧翼任务,考夫曼学术和教育成就测试第三版，分别。次要结果包括注意资源分配的事件相关脑电位和信息处理速度(即，P3/P300振幅和潜伏期）在侧翼任务期间记录。将使用异色闪烁光度法评估黄斑色素光密度（MPOD）。认知评估将在补充期完成之前和之后完成。MPOD将在之前量化，在（4-5个月）的中点，以及（9个月）补充期之后。假设补充LZ可以改善认知和学习成绩。Further,认知和成就的益处预计是由治疗组参与者中MC的增加介导的。
