Abstract：
OBJECTIVE: Nigella sativa oil is known antiallergic and immunomodulatory effects. We aimed to compare this oil with mometasone furoate, a topical steroid, on a rat model in the prevention of allergic rhinitis symptoms.
METHODS: A total of 28 two-to-four-month-old Wistar Hannover rats weighing 250-350 g were randomly divided into four groups of seven, which included control, allergic rhinitis, mometasone furoate, and Nigella sativa oil groups. Loss of cilia, an increase of goblet cells, vascular proliferation, inflammatory cell count, eosinophil infiltration, and the degree of hypertrophy in chondrocytes were assessed by light microscopy.
RESULTS: The frequency of nasal scratching in the Nigella sativa oil group was found to be significantly lower compared with the allergic rhinitis group (p < 0.05). Typical inflammatory changes seen in allergic rhinitis were not detected in the Nigella sativa oil group. No inflammation was observed in 85.7% of both the healthy control group and the Nigella sativa oil group. In addition, no inflammation was observed in 71.4% of the mometasone furoate group, and this difference was found to be significant compared with the control group (p < 0.05). In addition, eosinophil infiltration, cilia loss, chondrocyte hypertrophy, vascular proliferation, and goblet cell increase were found to be significantly decreased in the mometazone furoate and Nigella sativa oil groups compared to the allergic rhinitis group (p < 0.05).
CONCLUSIONS: According to the findings obtained from this study, we found anti-inflammatory and anti-allergic effects of Nigella sativa oil as equally effective as mometasone furoate in the treatment of experimentaly generated allergic rhinitis.
METHODS: IV.
METHODS: A total of 28 two-to-four-month-old Wistar Hannover rats weighing 250-350 g were randomly divided into four groups of seven, which included control, allergic rhinitis, mometasone furoate, and Nigella sativa oil groups. Loss of cilia, an increase of goblet cells, vascular proliferation, inflammatory cell count, eosinophil infiltration, and the degree of hypertrophy in chondrocytes were assessed by light microscopy.
RESULTS: The frequency of nasal scratching in the Nigella sativa oil group was found to be significantly lower compared with the allergic rhinitis group (p < 0.05). Typical inflammatory changes seen in allergic rhinitis were not detected in the Nigella sativa oil group. No inflammation was observed in 85.7% of both the healthy control group and the Nigella sativa oil group. In addition, no inflammation was observed in 71.4% of the mometasone furoate group, and this difference was found to be significant compared with the control group (p < 0.05). In addition, eosinophil infiltration, cilia loss, chondrocyte hypertrophy, vascular proliferation, and goblet cell increase were found to be significantly decreased in the mometazone furoate and Nigella sativa oil groups compared to the allergic rhinitis group (p < 0.05).
CONCLUSIONS: According to the findings obtained from this study, we found anti-inflammatory and anti-allergic effects of Nigella sativa oil as equally effective as mometasone furoate in the treatment of experimentaly generated allergic rhinitis.
METHODS: IV.
摘要：
目的：紫花苜蓿油是已知的抗过敏和免疫调节作用。我们的目的是将这种油与糠酸莫米松进行比较，一种局部类固醇,对大鼠模型中过敏性鼻炎症状的预防。
方法:将28只2-4个月大的WistarHannover大鼠随机分为4组,每组7只,其中包括控制，过敏性鼻炎,糠酸莫米松,和Nigellasativa油组。失去纤毛，杯状细胞的增加，血管增生,炎症细胞计数，嗜酸性粒细胞浸润,通过光学显微镜评估软骨细胞的肥大程度。
结果：发现与变应性鼻炎组相比，Nigellasativa油组的鼻刮擦频率显着降低（p<0.05）。在Nigellasavva油组中未检测到过敏性鼻炎中可见的典型炎症变化。在健康对照组和黑麦草油组的85.7%中未观察到炎症。此外,糠酸莫米松组71.4%未观察到炎症,与对照组相比，这种差异具有统计学意义（p<0.05）。此外,嗜酸性粒细胞浸润,纤毛损失,软骨细胞肥大，血管增生,发现与过敏性鼻炎组相比，糠酸莫米他松和紫花苜蓿油组的杯状细胞增加显着降低（p<0.05）。
结论：根据这项研究的结果，我们发现，在治疗实验性变应性鼻炎方面，黑麦草油的抗炎和抗过敏作用与糠酸莫米松同等有效。
方法：IV.
方法:将28只2-4个月大的WistarHannover大鼠随机分为4组,每组7只,其中包括控制，过敏性鼻炎,糠酸莫米松,和Nigellasativa油组。失去纤毛，杯状细胞的增加，血管增生,炎症细胞计数，嗜酸性粒细胞浸润,通过光学显微镜评估软骨细胞的肥大程度。
结果：发现与变应性鼻炎组相比，Nigellasativa油组的鼻刮擦频率显着降低（p<0.05）。在Nigellasavva油组中未检测到过敏性鼻炎中可见的典型炎症变化。在健康对照组和黑麦草油组的85.7%中未观察到炎症。此外,糠酸莫米松组71.4%未观察到炎症,与对照组相比，这种差异具有统计学意义（p<0.05）。此外,嗜酸性粒细胞浸润,纤毛损失,软骨细胞肥大，血管增生,发现与过敏性鼻炎组相比，糠酸莫米他松和紫花苜蓿油组的杯状细胞增加显着降低（p<0.05）。
结论：根据这项研究的结果，我们发现，在治疗实验性变应性鼻炎方面，黑麦草油的抗炎和抗过敏作用与糠酸莫米松同等有效。
方法：IV.
