Abstract：
Acute diarrhea is the most frequent diagnosis among ill travelers. Sleep loss may weaken the body\'s defense against pathogens and increase susceptibility to infection. The relationship between sleep and infectious diarrhea has not been studied and was assessed utilizing data from a controlled human infection model (CHIM) for enterotoxigenic Escherichia coli (ETEC).
During a CHIM assessing the efficacy of an immunoprophylactic targeting ETEC against moderate-to-severe diarrhea (MSD) following challenge, we measured sleep via actigraphy over an 8-day inpatient period. We hypothesized better sleep pre-challenge would predict illness symptomatology following challenge.
Among 57 participants (aged 34.4 ± 8.1 years, 64% male), there was no relationship between sleep metrics and incidence of MSD. However, longer total sleep time the night preceding ETEC challenge was associated with lower maximum 24 h diarrhea volume (B = -1.80, p = 0.01) and total diarrhea volume (B = -2.45, p = 0.01).
This novel study showed that shorter sleep duration predicted diarrhea severity over the course of an ETEC infection. Future work should experimentally manipulate sleep to further clarify its impact on diarrhea-related outcomes for ETEC and other important enteric pathogens.
During a CHIM assessing the efficacy of an immunoprophylactic targeting ETEC against moderate-to-severe diarrhea (MSD) following challenge, we measured sleep via actigraphy over an 8-day inpatient period. We hypothesized better sleep pre-challenge would predict illness symptomatology following challenge.
Among 57 participants (aged 34.4 ± 8.1 years, 64% male), there was no relationship between sleep metrics and incidence of MSD. However, longer total sleep time the night preceding ETEC challenge was associated with lower maximum 24 h diarrhea volume (B = -1.80, p = 0.01) and total diarrhea volume (B = -2.45, p = 0.01).
This novel study showed that shorter sleep duration predicted diarrhea severity over the course of an ETEC infection. Future work should experimentally manipulate sleep to further clarify its impact on diarrhea-related outcomes for ETEC and other important enteric pathogens.
摘要：
急性腹泻是患病旅行者中最常见的诊断。睡眠不足可能会削弱身体对病原体的防御，并增加对感染的易感性。尚未研究睡眠与感染性腹泻之间的关系，并利用来自产肠毒性大肠杆菌（ETEC）的受控人类感染模型（CHIM）的数据进行了评估。
在CHIM评估免疫预防性靶向ETEC对攻击后中度至重度腹泻（MSD）的疗效期间，我们通过肌动描记术测量了8天住院期间的睡眠。我们假设更好的睡眠前挑战可以预测挑战后的疾病症状学。
在57名参与者中（年龄34.4±8.1岁，64%男性），睡眠指标与MSD发生率之间没有关系.然而,ETEC攻击前一晚总睡眠时间越长,24h最大腹泻量(B=-1.80,p=0.01)和总腹泻量(B=-2.45,p=0.01)越低.
这项新的研究表明，在ETEC感染过程中，较短的睡眠时间可以预测腹泻的严重程度。未来的工作应该通过实验操纵睡眠，以进一步阐明其对ETEC和其他重要肠道病原体的腹泻相关结果的影响。
在CHIM评估免疫预防性靶向ETEC对攻击后中度至重度腹泻（MSD）的疗效期间，我们通过肌动描记术测量了8天住院期间的睡眠。我们假设更好的睡眠前挑战可以预测挑战后的疾病症状学。
在57名参与者中（年龄34.4±8.1岁，64%男性），睡眠指标与MSD发生率之间没有关系.然而,ETEC攻击前一晚总睡眠时间越长,24h最大腹泻量(B=-1.80,p=0.01)和总腹泻量(B=-2.45,p=0.01)越低.
这项新的研究表明，在ETEC感染过程中，较短的睡眠时间可以预测腹泻的严重程度。未来的工作应该通过实验操纵睡眠，以进一步阐明其对ETEC和其他重要肠道病原体的腹泻相关结果的影响。
