Abstract：
OBJECTIVE: It was aimed to systematically synthesise the available literature on examining the effect of chewing gum in the management/reduction of chemotherapy-induced oral mucositis in children.
METHODS: The PRISMA was followed for the systematic review. All published studies obtained from the relevant databases were examined while the research question and inclusion and exclusion criteria were considered. The Joanna Briggs Institute (JBI) critical appraisal tools were used to evaluate the quality of the studies.
RESULTS: A total of five studies met the inclusion criteria: three randomised controlled trials (RCT) and two quasi-experimental studies with a total of 461 paediatric oncology patients were included. Heterogeneity was found across all studies regarding the application of gum chewing and regarding the effectiveness of gum chewing. Two RTCs and one quasi-experimental study reported that gum chewing is not effective to reduce severe oral mucositis, but effective to reduce moderate and mild oral mucositis, and one RTC reported that gum chewing is not effective to reduce oral mucositis.
CONCLUSIONS: Experimental studies particularly randomised controlled trials using rigorous designs, consistent outcome measures, and larger sample sizes are required to determine the efficacy of chewing gum in reducing chemotherapy-induced oral mucositis in paediatric oncology patients. Study was registered in PROSPERO and number was CRD42022328916.
METHODS: The PRISMA was followed for the systematic review. All published studies obtained from the relevant databases were examined while the research question and inclusion and exclusion criteria were considered. The Joanna Briggs Institute (JBI) critical appraisal tools were used to evaluate the quality of the studies.
RESULTS: A total of five studies met the inclusion criteria: three randomised controlled trials (RCT) and two quasi-experimental studies with a total of 461 paediatric oncology patients were included. Heterogeneity was found across all studies regarding the application of gum chewing and regarding the effectiveness of gum chewing. Two RTCs and one quasi-experimental study reported that gum chewing is not effective to reduce severe oral mucositis, but effective to reduce moderate and mild oral mucositis, and one RTC reported that gum chewing is not effective to reduce oral mucositis.
CONCLUSIONS: Experimental studies particularly randomised controlled trials using rigorous designs, consistent outcome measures, and larger sample sizes are required to determine the efficacy of chewing gum in reducing chemotherapy-induced oral mucositis in paediatric oncology patients. Study was registered in PROSPERO and number was CRD42022328916.
摘要：
目的：旨在系统地综合现有文献，研究口香糖在治疗/减少儿童化疗引起的口腔黏膜炎中的作用。
方法：遵循PRISMA进行系统评价。检查了从相关数据库获得的所有已发表的研究，同时考虑了研究问题以及纳入和排除标准。JoannaBriggs研究所（JBI）的关键评估工具被用来评估研究的质量。
结果：共有5项研究符合纳入标准：3项随机对照试验（RCT）和2项准实验研究，共纳入461名儿科肿瘤患者。在关于口香糖的应用和关于口香糖的有效性的所有研究中都发现了异质性。两个RTC和一个准实验研究报告说，口香糖不能有效减少严重的口腔粘膜炎，但有效减少中度和轻度口腔粘膜炎，和一个RTC报告说，嚼口香糖不能有效减少口腔粘膜炎。
结论：实验研究，特别是使用严格设计的随机对照试验，一致的结果衡量标准，并且需要更大的样本量来确定口香糖在减少儿科肿瘤患者化疗引起的口腔黏膜炎方面的功效。研究在PROSPERO注册，编号为CRD42022328916。
方法：遵循PRISMA进行系统评价。检查了从相关数据库获得的所有已发表的研究，同时考虑了研究问题以及纳入和排除标准。JoannaBriggs研究所（JBI）的关键评估工具被用来评估研究的质量。
结果：共有5项研究符合纳入标准：3项随机对照试验（RCT）和2项准实验研究，共纳入461名儿科肿瘤患者。在关于口香糖的应用和关于口香糖的有效性的所有研究中都发现了异质性。两个RTC和一个准实验研究报告说，口香糖不能有效减少严重的口腔粘膜炎，但有效减少中度和轻度口腔粘膜炎，和一个RTC报告说，嚼口香糖不能有效减少口腔粘膜炎。
结论：实验研究，特别是使用严格设计的随机对照试验，一致的结果衡量标准，并且需要更大的样本量来确定口香糖在减少儿科肿瘤患者化疗引起的口腔黏膜炎方面的功效。研究在PROSPERO注册，编号为CRD42022328916。
