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Abstract：
To investigate the distribution and clinical significance of the rods and rings (RR) pattern in various diseases.
A total of 169,891 patients in Peking Union Medical College Hospital (PUMCH) and 29,458 patients in Inner Mongolia People\'s Hospital (IMPH) from January 2018 to December 2020 were included, and the results of ANA (antinuclear antibodies) and special antibodies were analyzed retrospectively.
The positive rates of ANA and RR patterns were 34.84%, 0.16% in PUMCH, and 44.73%, 0.23% in IMPH. Anti-RR antibodies mainly appear in adults (≥ 41 years), mostly of low or medium fluorescence titers. Isolated RR patterns were mostly presented (60.30% and 69.12%, respectively), and the RR pattern mixed with the speckled pattern was most commonly observed among patients having two or more patterns. The RR pattern existed in a variety of diseases including hepatitis C, AIDs, pulmonary diseases, nephropathy diseases, and even healthy people. The highest prevalence of the RR pattern was observed in hepatic diseases, such as hepatic dysfunction (0.79%), hepatic cirrhosis (1.05%), PBC (0.85%), and AIH (0.65%), etc. The positive rate of specific antibodies in RR pattern cases was 31.25%, and anti-Ro52 (27, 20.61%) was the most common target antibody.
The RR pattern had a low prevalence in ANAs test samples and varied in different nationalities and regions. Except for hepatitis C, it could be observed in AIDs, pulmonary diseases, nephropathy, other hepatic diseases, and even healthy people, but the positive rate was slightly higher in hepatic diseases. Its mechanism of action and clinical relevance still need clarification.
A total of 169,891 patients in Peking Union Medical College Hospital (PUMCH) and 29,458 patients in Inner Mongolia People\'s Hospital (IMPH) from January 2018 to December 2020 were included, and the results of ANA (antinuclear antibodies) and special antibodies were analyzed retrospectively.
The positive rates of ANA and RR patterns were 34.84%, 0.16% in PUMCH, and 44.73%, 0.23% in IMPH. Anti-RR antibodies mainly appear in adults (≥ 41 years), mostly of low or medium fluorescence titers. Isolated RR patterns were mostly presented (60.30% and 69.12%, respectively), and the RR pattern mixed with the speckled pattern was most commonly observed among patients having two or more patterns. The RR pattern existed in a variety of diseases including hepatitis C, AIDs, pulmonary diseases, nephropathy diseases, and even healthy people. The highest prevalence of the RR pattern was observed in hepatic diseases, such as hepatic dysfunction (0.79%), hepatic cirrhosis (1.05%), PBC (0.85%), and AIH (0.65%), etc. The positive rate of specific antibodies in RR pattern cases was 31.25%, and anti-Ro52 (27, 20.61%) was the most common target antibody.
The RR pattern had a low prevalence in ANAs test samples and varied in different nationalities and regions. Except for hepatitis C, it could be observed in AIDs, pulmonary diseases, nephropathy, other hepatic diseases, and even healthy people, but the positive rate was slightly higher in hepatic diseases. Its mechanism of action and clinical relevance still need clarification.
摘要：
目的探讨杆和环(RR)模式在各种疾病中的分布及临床意义。
共纳入2018年1月至2020年12月北京协和医院（PUMCH）的169,891例患者和内蒙古人民医院（IMPH）的29,458例患者。并对ANA（抗核抗体）和特殊抗体的结果进行回顾性分析。
ANA和RR模式的阳性率为34.84％，PUMCH中的0.16%，和44.73%，IMPH中的0.23%。抗RR抗体主要出现在成人（≥41岁），主要是低或中等的荧光滴度。主要呈现孤立的RR模式(60.30%和69.12%，分别)，在有两种或两种以上模式的患者中，最常观察到RR模式与斑点模式混合。RR模式存在于包括丙型肝炎在内的多种疾病中，艾滋病,肺部疾病，肾病疾病，甚至健康的人。在肝病中观察到RR模式的患病率最高，如肝功能障碍（0.79％），肝硬化（1.05%），中国人民银行（0.85%），和AIH（0.65%），等。RR型病例特异性抗体阳性率为31.25%,抗Ro52（27，20.61%）是最常见的靶抗体。
RR模式在ANA测试样本中患病率较低，并且在不同民族和地区有所不同。除了丙型肝炎,它可以在艾滋病中观察到，肺部疾病，肾病，其他肝病,甚至健康的人，但在肝病中阳性率略高。其作用机制和临床相关性仍有待澄清。
共纳入2018年1月至2020年12月北京协和医院（PUMCH）的169,891例患者和内蒙古人民医院（IMPH）的29,458例患者。并对ANA（抗核抗体）和特殊抗体的结果进行回顾性分析。
ANA和RR模式的阳性率为34.84％，PUMCH中的0.16%，和44.73%，IMPH中的0.23%。抗RR抗体主要出现在成人（≥41岁），主要是低或中等的荧光滴度。主要呈现孤立的RR模式(60.30%和69.12%，分别)，在有两种或两种以上模式的患者中，最常观察到RR模式与斑点模式混合。RR模式存在于包括丙型肝炎在内的多种疾病中，艾滋病,肺部疾病，肾病疾病，甚至健康的人。在肝病中观察到RR模式的患病率最高，如肝功能障碍（0.79％），肝硬化（1.05%），中国人民银行（0.85%），和AIH（0.65%），等。RR型病例特异性抗体阳性率为31.25%,抗Ro52（27，20.61%）是最常见的靶抗体。
RR模式在ANA测试样本中患病率较低，并且在不同民族和地区有所不同。除了丙型肝炎,它可以在艾滋病中观察到，肺部疾病，肾病，其他肝病,甚至健康的人，但在肝病中阳性率略高。其作用机制和临床相关性仍有待澄清。
