Abstract：
Using a biomimetic strategy and bioinspired materials, our work proposed a new technological approach to create a hybrid transitional layer between enamel and dental biocomposite. For this purpose, an amino acid booster conditioner based on a set of polar amino acids (lysine, arginine, hyaluronic acid), calcium alkali, and a modified adhesive based on BisGMA and nanocrystalline carbonate-substituted hydroxyapatite are used during dental enamel restoration. The molecular properties of the hybrid interface formed using the proposed strategy were understood using methods of multivariate statistical analysis of spectral information collected using the technique of synchrotron infrared microspectroscopy. The results obtained indicate the possibility of forming a bonding that mimics the properties of natural tissue with controlled molecular properties in the hybrid layer. The diffusion of the amino acid booster conditioner component, the calcium alkali, and the modified adhesive with nanocrystalline carbonate-substituted hydroxyapatite in the hybrid interface region creates a structure that should stabilize the reconstituted crystalline enamel layer. The developed technology can form the basis for an individualized, personalized approach to dental enamel restorations.
摘要：
使用仿生策略和生物启发材料，我们的工作提出了一种新的技术方法来创建牙釉质和牙科生物复合材料之间的混合过渡层。为此,一种基于一组极性氨基酸(赖氨酸，精氨酸透明质酸），钙碱，并在牙釉质修复过程中使用基于BisGMA和纳米晶碳酸盐取代的羟基磷灰石的改性粘合剂。使用同步加速器红外显微光谱技术收集的光谱信息的多元统计分析方法，可以理解使用所提出的策略形成的混合界面的分子特性。获得的结果表明，在混合层中形成模拟具有受控分子特性的天然组织特性的键合的可能性。氨基酸助推器调理剂组分的扩散，钙碱，并且在混合界面区域中具有纳米结晶碳酸盐取代的羟基磷灰石的改性粘合剂产生应稳定重构的结晶釉质层的结构。开发的技术可以形成个性化的基础，牙釉质修复的个性化方法。
