PDF(Pubmed)
Abstract：
A systematic review and meta-analysis were carried out to evaluate the efficacy of silver diamine fluoride (SDF) in controlling caries progression in cavitated primary molars. A search for randomized and non-randomized trials with follow-up > 6 months was performed using PubMed, Scopus and Embase. The Cochrane risk of bias tools were used for the quality assessment. The success rate and odds ratios were chosen to calculate the effect size for the meta-analysis. A total of 792 papers were identified and 9 were selected. A high variability regarding SDF application protocol was found; otherwise, caries arrest was always recorded using visual/tactile methods. Two studies were judged at low risk of bias, six at moderate risk and one at high risk. Data from five studies were aggregated for meta-analysis. Heterogeneity was found moderate (I2 = 35.69%, p = 0.18). SDF application was found to be overall effective (fixed effect model) in arresting caries progression (ES = 0.35, p < 0.01). In a total of 622 arrested lesions, out of 1205 considered, the caries arrest rate was 51.62% ± 27.40% (Confidence = 1.55) using SDF ≥ 38% applied annually or biannually. In conclusion, when applied to active cavitated caries lesions in primary molars, SDF appears to be effective in arresting dental caries progression, especially if applied biannually.
摘要：
进行了系统评价和荟萃分析，以评估氟化银二胺（SDF）在控制空化乳牙龋齿进展中的功效。使用PubMed搜索随访>6个月的随机和非随机试验，Scopus和Embase.使用Cochrane偏差风险工具进行质量评估。选择成功率和优势比来计算荟萃分析的效果大小。共鉴定了792篇论文，并选择了9篇。发现有关SDF应用协议的高度可变性；否则，龋齿停滞总是使用视觉/触觉方法记录。两项研究的偏倚风险较低，六个处于中等风险，一个处于高风险。对5项研究的数据进行汇总进行荟萃分析。发现异质性中等(I2=35.69%，p=0.18）。发现SDF应用在阻止龋齿进展方面是总体有效的(固定效应模型)(ES=0.35,p<0.01)。在总共622个被捕的病灶中，在1205个考虑中，使用每年或每半年应用的SDF≥38％，龋齿阻止率为51.62％±27.40％（置信度=1.55）。总之,当应用于原发性磨牙的活动性空化龋齿病变时，SDF似乎可以有效阻止龋齿的发展，尤其是每半年申请一次。
