PDF(Pubmed)
Abstract：
Toxoplasma gondii belongs to the phylum Apicomplexa and is an important cause of congenital disease and infection in immunocompromised patients. T. gondii shares several characteristics with plants including a nonphotosynthetic plastid termed apicoplast and a multivesicular organelle that was named the plant-like vacuole (PLV) or vacuolar compartment (VAC). The name plant-like vacuole was selected based on its resemblance in composition and function to plant vacuoles. The name VAC represents its general vacuolar characteristics. We will refer to the organelle as PLVAC in this review. New findings in recent years have revealed that the PLVAC represents the lysosomal compartment of T. gondii which has adapted peculiarities to fulfill specific Toxoplasma needs. In this review, we discuss the composition and functions of the PLVAC highlighting its roles in ion storage and homeostasis, endocytosis, exocytosis, and autophagy.
摘要：
弓形虫属于顶孔门，是免疫功能低下患者先天性疾病和感染的重要原因。弓形虫与植物具有多种特征，包括称为原生质体的非光合质体和称为植物性液泡（PLV）或液泡室（VAC）的多囊细胞器。基于其与植物液泡在组成和功能上的相似性，选择了植物样液泡的名称。名称VAC代表其一般的液泡特征。在这篇综述中，我们将细胞器称为PLVAC。近年来的新发现表明，PLVAC代表弓形虫的溶酶体区室，其适应了特定的弓形虫需求。在这次审查中,我们讨论了PLVAC的组成和功能，强调了它在离子储存和稳态中的作用，内吞作用,胞吐作用,和自噬。
