PDF(Pubmed)
Abstract：
UNASSIGNED: Magnetic resonance-guided radiotherapy (MRgRT) with real-time intra-fraction tumor motion monitoring allows for high precision Stereotactic Ablative Radiotherapy (SABR). This study aimed to investigate the clinical feasibility, patient satisfaction and delivery accuracy of single-fraction MR-guided SABR in a single day (one-stop-shop, OSS).
UNASSIGNED: Ten patients with small lung tumors eligible for single fraction treatments were included. The OSS procedure consisted of consultation, treatment simulation, treatment planning and delivery. Following SABR delivery, patients completed a reported experience measure (PREM) questionnaire. Prescribed doses ranged 28-34 Gy. Median GTV was 2.2 cm3 (range 1.3-22.9 cm3). A gating boundary of 3 mm, and PTV margin of 5 mm around the GTV, were used with auto-beam delivery control. Accuracy of SABR delivery was studied by analyzing delivered MR-cines reconstructed from machine log files.
UNASSIGNED: All 10 patients completed the OSS procedure in a single day, and all reported satisfaction with the process. Median time for the treatment planning step and the whole procedure were 2.8 h and 6.6 h, respectively. With optimization of the procedure, treatment could be completed in half a day. During beam-on, the 3 mm tracking boundary encompassed between 78.0 and 100 % of the GTV across all patients, with corresponding PTV values being 94.4-100 % (5th-95th percentiles). On average, system-latency for triggering a beam-off event comprised 5.3 % of the delivery time. Latency reduced GTV coverage by an average of -0.3 %. Duty-cycles during treatment delivery ranged from 26.1 to 64.7 %.
UNASSIGNED: An OSS procedure with MR-guided SABR for lung cancer led to good patient satisfaction. Gated treatment delivery was highly accurate with little impact of system-latency.
UNASSIGNED: Ten patients with small lung tumors eligible for single fraction treatments were included. The OSS procedure consisted of consultation, treatment simulation, treatment planning and delivery. Following SABR delivery, patients completed a reported experience measure (PREM) questionnaire. Prescribed doses ranged 28-34 Gy. Median GTV was 2.2 cm3 (range 1.3-22.9 cm3). A gating boundary of 3 mm, and PTV margin of 5 mm around the GTV, were used with auto-beam delivery control. Accuracy of SABR delivery was studied by analyzing delivered MR-cines reconstructed from machine log files.
UNASSIGNED: All 10 patients completed the OSS procedure in a single day, and all reported satisfaction with the process. Median time for the treatment planning step and the whole procedure were 2.8 h and 6.6 h, respectively. With optimization of the procedure, treatment could be completed in half a day. During beam-on, the 3 mm tracking boundary encompassed between 78.0 and 100 % of the GTV across all patients, with corresponding PTV values being 94.4-100 % (5th-95th percentiles). On average, system-latency for triggering a beam-off event comprised 5.3 % of the delivery time. Latency reduced GTV coverage by an average of -0.3 %. Duty-cycles during treatment delivery ranged from 26.1 to 64.7 %.
UNASSIGNED: An OSS procedure with MR-guided SABR for lung cancer led to good patient satisfaction. Gated treatment delivery was highly accurate with little impact of system-latency.
摘要：
UNASSIGNED：磁共振引导放射治疗（MRgRT）与实时肿瘤内运动监测允许高精度立体定向消融放射治疗（SABR）。本研究旨在探讨临床可行性,患者满意度和单级MR引导SABR在一天内的交付准确性(一站式，OSS）。
UNASSIGNED：纳入了10例有资格接受单部分治疗的肺小肿瘤患者。OSS程序包括协商，治疗模拟，治疗计划和交付。SABR交货后,患者完成了报告的经验测量(PREM)问卷.处方剂量范围为28-34Gy。中值GTV为2.2cm3(范围1.3-22.9cm3)。3毫米的门控边界，和围绕GTV的5毫米的PTV边缘，与自动光束输送控制一起使用。通过分析从机器日志文件重建的已交付MR-cines来研究SABR交付的准确性。
UNASSIGNED：所有10名患者在一天内完成了OSS程序，所有人都报告对这个过程感到满意。治疗计划步骤和整个过程的中位时间分别为2.8h和6.6h，分别。随着程序的优化，治疗可以在半天内完成。在开束期间，3毫米的跟踪边界涵盖了所有患者的78.0％至100％的GTV，相应的PTV值为94.4-100%(第5-第95百分位数)。平均而言,触发波束关闭事件的系统延迟占交付时间的5.3%。延迟使GTV覆盖率平均降低-0.3%。治疗期间的占空比范围为26.1％至64.7％。
UASSIGNED：采用MR引导SABR治疗肺癌的OSS程序可使患者获得良好的满意度。门控治疗递送非常准确，对系统延迟的影响很小。
UNASSIGNED：纳入了10例有资格接受单部分治疗的肺小肿瘤患者。OSS程序包括协商，治疗模拟，治疗计划和交付。SABR交货后,患者完成了报告的经验测量(PREM)问卷.处方剂量范围为28-34Gy。中值GTV为2.2cm3(范围1.3-22.9cm3)。3毫米的门控边界，和围绕GTV的5毫米的PTV边缘，与自动光束输送控制一起使用。通过分析从机器日志文件重建的已交付MR-cines来研究SABR交付的准确性。
UNASSIGNED：所有10名患者在一天内完成了OSS程序，所有人都报告对这个过程感到满意。治疗计划步骤和整个过程的中位时间分别为2.8h和6.6h，分别。随着程序的优化，治疗可以在半天内完成。在开束期间，3毫米的跟踪边界涵盖了所有患者的78.0％至100％的GTV，相应的PTV值为94.4-100%(第5-第95百分位数)。平均而言,触发波束关闭事件的系统延迟占交付时间的5.3%。延迟使GTV覆盖率平均降低-0.3%。治疗期间的占空比范围为26.1％至64.7％。
UASSIGNED：采用MR引导SABR治疗肺癌的OSS程序可使患者获得良好的满意度。门控治疗递送非常准确，对系统延迟的影响很小。
