Abstract：
Malignant syphilis (MS) is a rare dermatological manifestation of secondary syphilis. This case report describes a young woman that presented with a 15-day history of generalized condyloma lata and seborrheic dermatitis-like lesions at various stages. Laboratory tests showed a toluidine red unheated serum test titre of 1:128 and Treponema pallidum particle agglutination positivity. Serology for HIV antibodies was repeatedly negative. MS was diagnosed according to established MS diagnostic criteria. The lesions regressed after treatment with 2 400 000 units penicillin G benzathine by intramuscular injection weekly for three consecutive weeks. MS is more frequently associated with HIV-infected patients, which makes this current case more interesting because MS in HIV-negative patients has rarely been reported.
摘要：
恶性梅毒（MS）是继发性梅毒的罕见皮肤病学表现。该病例报告描述了一名年轻女性，该女性在各个阶段均有15天的全身性湿疣和脂溢性皮炎样病变病史。实验室测试显示，甲苯胺红色未加热血清试验滴度为1：128，梅毒螺旋体颗粒凝集阳性。HIV抗体的血清学反复呈阴性。根据建立的MS诊断标准诊断MS。连续三周每周肌肉注射2400000单位青霉素G苄星治疗后，病变消退。MS更频繁地与HIV感染患者相关，这使得目前的病例更有趣，因为HIV阴性患者中的MS很少被报道。
