PDF(Pubmed)
Abstract：
Background: Calcium oxalate kidney stone is one of the common diseases in the urinary system and has a high recurrence rate. Currently, the pathogenesis of kidney stone and the methods to prevent recurrence are still being investigated. Autophagy, as an event of cellular self-repair, has received attention in the field of kidney stone in recent years. In some current studies, autophagy has shown destructiveness and protectiveness in the pathogenesis of kidney stone. The inhibition or promotion of autophagy may be a key target for future kidney stone therapy. This systematic literature review discusses the function of autophagy in kidney stone pathogenesis in the context of current research and synthesizes the evidence analysis to provide a basis for new future therapies. Method: We systematically reviewed the literature during September 2021 according to the Preferred Reporting Items for Systematic Evaluation and Meta-Analysis (PRISMA) guidelines. Articles on studying the role of autophagy in the pathogenesis of calcium oxalate kidney stone were extracted from PubMed, MEDLINE, Embase and Scopus, including in vivo versus in vitro experiments. The study topic, language and publication date were not restricted. Two authors (Li and Zhou) searched and screened the literature. Results: We screened 18 articles from the 33 collected articles, of which 6 conducted in vitro cellular studies, four conducted animal studies, eight conducted cellular studies with animal studies, and five studied human specimens. In early studies, the literature generally concluded that autophagy is deleterious in the development of kidney stone. In 2020, the idea of the protectiveness of autophagy associated with kidney stone was first proposed and focused on targeting transcription factor EB. In addition, the interaction of autophagy with other cellular events and the regulation of signaling molecules are focused on in this paper. Conclusion: This systematic review provides advances in research on the role of autophagy in renal calculi. The current studies suggest that both upregulation and downregulation of autophagy may ameliorate injury in kidney stone models. The authors prefer the upregulation of autophagy as a future research direction for kidney stone treatment.
摘要：
背景:草酸钙肾结石是泌尿系统常见疾病之一,复发率高。目前,肾结石的发病机制和预防复发的方法仍在研究中。自噬,作为细胞自我修复的事件，近年来在肾结石领域受到关注。在当前的一些研究中,自噬在肾结石的发病机制中显示出破坏性和保护性。抑制或促进自噬可能是未来肾结石治疗的关键靶点。本系统文献综述在当前研究的背景下探讨自噬在肾结石发病机制中的作用，并综合证据分析，为未来新的治疗提供依据。方法：我们根据系统评估和荟萃分析（PRISMA）指南的首选报告项目，系统回顾了2021年9月的文献。研究自噬在草酸钙肾结石发病机制中的作用的文章摘自PubMed,MEDLINE,Embase和Scopus,包括体内与体外实验。研究主题,语言和出版日期不受限制。两位作者（李和周）搜索并筛选了文献。结果：我们从收集的33篇文章中筛选出18篇文章，其中6人进行了体外细胞研究，四次进行的动物研究，八个进行了细胞研究和动物研究，和五个研究的人体标本。在早期研究中,文献普遍认为自噬在肾结石的发生发展中有害。2020年，首次提出了与肾结石相关的自噬保护性的想法，并将重点放在靶向转录因子EB上。此外,本文重点研究了自噬与其他细胞事件的相互作用以及信号分子的调控。结论：本系统综述提供了自噬在肾结石中作用的研究进展。目前的研究表明，自噬的上调和下调都可能改善肾结石模型的损伤。作者更倾向于将自噬上调作为肾结石治疗的未来研究方向。
