Abstract：
Liver fibrosis is a major health concern occurring worldwide. It arises due to prolonged wound healing response of various insults like viral, autoimmune, cholestatic, drug-induced, and metabolic diseases. Currently, there is no clinically approved drug for liver fibrosis treatment. Hepatic stellate cells are the principal liver cells that are activated during liver fibrosis, and targeting these activated cells is an ideal therapeutic strategy. Numerous phytochemicals have been demonstrated in vitro and in vivo treating experimental liver fibrosis; however, none of them have been clinically approved for therapeutic use. This review mainly focuses on such hepatoprotective phytochemicals reported inhibiting major signaling pathways that are dysregulated in activated hepatic stellate cells. PRACTICAL APPLICATIONS: Liver fibrosis is a global health concern and there is no FDA approved drug to treat liver fibrosis. Although notable pharmacological agents like pentoxifylline, gliotoxin, imatinibmesylate, Gleevec, and so on are reported to exhibit anti-fibrotic effect, the major concern is their side effect. Hence, phytochemicals are promising candidates that could be employed against liver fibrosis. In this review, the anti-fibrotic potential of phytochemicals targeting activated HSCs are summarized. Understanding these phytochemicals will further help in the development of agents that are more effective against liver fibrosis.
摘要：
肝纤维化是全球范围内发生的主要健康问题。它是由于各种损伤如病毒的延长伤口愈合反应而产生的，自身免疫，胆汁淤积,药物诱导，和代谢性疾病。目前,目前尚无临床批准的肝纤维化治疗药物。肝星状细胞是肝纤维化过程中被激活的主要肝细胞，靶向这些激活的细胞是一种理想的治疗策略。许多植物化学物质已被证明在体外和体内治疗实验性肝纤维化;然而，它们都没有被临床批准用于治疗。这篇综述主要集中在这些报道的抑制激活的肝星状细胞中失调的主要信号通路的保肝植物化学物质。实际应用：肝纤维化是一个全球性的健康问题，没有FDA批准的药物来治疗肝纤维化。尽管著名的药物如己酮可可碱，神经胶质毒素,伊马替尼甲磺酸酯,格列卫,等等，据报道表现出抗纤维化作用，主要关注的是它们的副作用。因此，植物化学物质是有希望的候选人，可用于对抗肝纤维化。在这次审查中,总结了针对活化HSC的植物化学物质的抗纤维化潜力。了解这些植物化学物质将进一步有助于开发更有效对抗肝纤维化的药物。
